Train High Eat Low for Osteoarthritis study (THE LO study): protocol for a randomized controlled trial

Journal of Physiotherapy
Yareni GuerreroMaria Fiatarone Singh

Abstract

Osteoarthritis (OA) is one of the most prevalent chronic conditions among older adults, with the medial tibio-femoral joint being most frequently affected. The knee adduction moment is recognized as a surrogate measure of the medial tibio-femoral compartment joint load and therefore represents a valid intervention target. This article provides the rationale and methodology for THE LO study (Train High, Eat Low for Osteoarthritis), which is a randomized controlled trial that is investigating the effects of a unique, targeted lifestyle intervention in overweight/obese adults with symptomatic medial knee OA. Compared to a control group given only lifestyle advice, do the effects of the following interventions result in significant reductions in the knee adduction moment: (1) gait retraining; and (2) combined intervention (which involves a combination of three interventions: (a) gait retraining, (b) high-intensity progressive resistance training, and (c) high-protein/low-glycaemic-index energy-restricted diet)? It is hypothesized that the combined intervention group will be superior to the isolated interventions of the high-protein/low-glycaemic-index diet group and the progressive resistance training group. Finally, it is hypothes...Continue Reading

Citations

Jun 23, 2020·Expert Opinion on Therapeutic Targets·Jo NijsAnneleen Malfliet
Oct 6, 2021·European Journal of Translational Myology·Jose Fuentes-LopezRossana Gomez Campos

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