Training effects in mice after long-term voluntary exercise

Medicine and Science in Sports and Exercise
Sara R DavidsonLaurie Hoffman-Goetz

Abstract

Mice are an important animal model in exercise studies on the immune system, cancer, and aging. There is limited research about the training effects of long-term voluntary exercise in this species. To describe the training effects in mice given long-term aerobic voluntary exercise. Female C57BL/6 mice were randomly assigned to 1) individual cages with in-cage running wheels with 24-h access (WR; N = 31), or 2) individual cages without running wheels for 16 wk (NR; N = 20). Run-to-exhaustion (RTE) times, VO2peak, speed at VO2peak, and citrate synthase (CS), succinate dehydrogenase (SDH), and phosphofructokinase (PFK) activity in the soleus, plantaris, and red and white gastrocnemius were assessed. Final body weight and speed at VO2peak did not differ by training condition. WR mice had significantly longer RTE times (P < 0.001) and higher VO2peak (P < 0.05) compared with NR mice. Higher CS and SDH activities were found in WR compared with NR mice for soleus (P < 0.01), red gastrocnemius (P < 0.01), and plantaris (P < 0.01) muscles. PFK activity was higher in WR mice in white gastrocnemius compared with NR mice (P < 0.01). Voluntary running wheel activity for 16 wk in female C57BL/6 mice resulted in longer run times to exhaustion,...Continue Reading

References

Apr 1, 1975·The American Journal of Physiology·R H FittsJ O Holloszy
Apr 1, 1976·The American Journal of Physiology·R L Terjung
Aug 1, 1992·Journal of Applied Physiology·C A SlentzJ O Holloszy
Jul 11, 1992·Physiology & Behavior·W A FriedmanM R Dohm
Jan 1, 1990·Journal of Applied Physiology·M I Lambert, T D Noakes
Apr 1, 1989·Journal of Applied Physiology·M I Lambert, T D Noakes
May 1, 1986·Journal of Applied Physiology·G J BagbyR E Shepherd
Jul 1, 1986·Journal of Applied Physiology·J M OvertonJ R Leininger
Sep 1, 1983·Physiology & Behavior·L Hoffman-Goetz, M A MacDonald
Mar 1, 1983·The American Journal of Physiology·M M ChiO H Lowry
Jan 1, 1995·The American Journal of Physiology·E J Henriksen, A E Halseth
Jan 1, 1993·Journal of Applied Physiology·B MacNeil, L Hoffman-Goetz
Sep 1, 1995·Journal of Applied Physiology·A E HalsethE J Henriksen
Feb 1, 1997·The Japanese Journal of Physiology·H YanoE Tsuji
Jan 22, 1998·The American Journal of Physiology·N OkaY Ishikawa
Apr 8, 1999·Journal of Applied Physiology·D A PodolinM J Pagliassotti
Sep 27, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·A MoraskaM Fleshner
Mar 16, 2002·Journal of Applied Physiology·I Girard, T Garland
Oct 26, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jay CampisiMonika Fleshner
Mar 17, 2004·Journal of Applied Physiology·Mark R ZielinskiJeffrey A Woods
Sep 4, 2004·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·I Mark OlfertOdile Mathieu-Costello
May 10, 2005·The Journal of Physiology·Patrick T FuegerDavid H Wasserman
May 17, 2005·Journal of Applied Physiology·Kristen A MehlJames A Carson

❮ Previous
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Citations

Jan 30, 2014·Longevity & Healthspan·Rebeca Garcia-VallesJose Viña
Aug 12, 2006·Canadian Journal of Physiology and Pharmacology·J Boudreau, L Hoffman-Goetz
Dec 5, 2009·Journal of Applied Physiology·Lee W JonesMark W Dewhirst
Jun 1, 2012·Canadian Journal on Aging = La Revue Canadienne Du Vieillissement·Nicholas Packer, Laurie Hoffman-Goetz
Aug 14, 2012·Revista española de geriatría y gerontología·Helios Pareja-GaleanoJosé Viña
Jan 11, 2012·Neuroscience and Biobehavioral Reviews·Colleen M NovakJames A Levine
Dec 7, 2007·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Naser Ahmadi AslSaeed Khamnei
Sep 26, 2008·Muscle & Nerve·Rachel M LandischDawn A Lowe
Nov 11, 2014·British Journal of Haematology·Emmanuelle CharrinCyril Martin
Aug 19, 2008·Vaccine·Connie J RogersJohn W Greiner
Nov 1, 2016·Journal of Cardiovascular Translational Research·Bryana M LevitanJonathan Satin
Sep 10, 2017·Basic Research in Cardiology·John J GuersStephen F Vatner
Feb 12, 2017·Journal of Applied Physiology·Daniel GamuA Russell Tupling
May 3, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Irene Martinez de TodaMonica De la Fuente
Sep 7, 2006·American Journal of Physiology. Endocrinology and Metabolism·Sebastian B JørgensenErik A Richter
Jul 4, 2009·Journal of Applied Physiology·Frank W BoothEspen E Spangenburg
Jun 12, 2010·Journal of Applied Physiology·J Timothy LightfootAlicia Hamilton
Feb 11, 2012·American Journal of Physiology. Cell Physiology·Jeff R S LeiterJudy E Anderson
Sep 17, 2019·Medicine and Science in Sports and Exercise·Harrison D StierwaltSean A Newsom
Sep 22, 2007·The Journal of Nutrition·Ricki J ColmanKurt W Saupe
Sep 11, 2019·Journal of the American Society of Nephrology : JASN·Keith G AvinSharon M Moe
Feb 14, 2012·Experimental Biology and Medicine·Emeline AufradetEmmanuelle Canet-Soulas
Mar 23, 2017·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Mari Carmen Gomez-CabreraJose Viña
Oct 27, 2020·Fly·Deena DamschroderRobert Wessells

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