Training improves the speed of aimed movements in Parkinson's disease

Brain : a Journal of Neurology
T PlatzC D Marsden

Abstract

In this study, the extent to which bradykinesia in patients with idiopathic Parkinson's disease can be influenced by practice and by specific training strategies was investigated. Fifteen patients with Parkinson's disease tested after withdrawal of anti-Parkinson medication, and 15 matched control subjects, practised a ballistic aiming task. Performance was tested before, during and after training and again 1 h later. The Parkinson's disease patients and control subjects were randomly assigned to one of two training schedules, practising with or without rhythmic auditory cues. At baseline, the Parkinson's disease patients showed longer movement times, with a marked decrease in maximum acceleration and deceleration in the initial open-loop phase compared with those of the control subjects. With training, they were able to make significant improvement in the speed of aimed movements, particularly in the early movement phase, without any deterioration in accuracy. These effects transferred to an untrained limb and were at least partially maintained after a 1-h delay. While patients remained impaired relative to control subjects at all phases of training and follow-up, the patients' performance at the end of training did not differ...Continue Reading

Citations

Sep 29, 2000·Movement Disorders : Official Journal of the Movement Disorder Society·J G NuttG J Sexton
Sep 29, 2000·Movement Disorders : Official Journal of the Movement Disorder Society·R MarcheseG Abbruzzese
Dec 5, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·Ann L Smiley-OyenCarol L Cross
Apr 29, 2011·Experimental Brain Research·S Levy-TzedekH Poizner
Dec 12, 2003·Archives of Physical Medicine and Rehabilitation·Marcus PohlJan Mehrholz
Mar 15, 2003·Progress in Neurobiology·J H McAuley
Jun 6, 2002·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Josep Valls-Solé, Francesc Valldeoriola
Dec 4, 2003·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·D FlamentD M Corcos
Feb 1, 2003·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Mark W RogersLois D Hedman
Oct 14, 2006·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M HorstinkUNKNOWN Movement Disorder Society-European Section
Jul 16, 2011·PloS One·Lisa Katharina PendtHermann Müller
Feb 9, 2010·Neurology India·Hamid Reza Rostami, Hassan Ashayeri
Sep 24, 2011·Parkinson's Disease·Quincy J Almeida, Haseel Bhatt
Apr 25, 2006·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Annette SterrSusanna Freivogel
Sep 12, 2013·PM & R : the Journal of Injury, Function, and Rehabilitation·Mohan GanesanPramod Kumar Pal
Sep 25, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Rocco AgostinoAlfredo Berardelli
Feb 9, 2010·Revue neurologique·J-M Gracies
Mar 1, 2009·PM & R : the Journal of Injury, Function, and Rehabilitation·Alex MorozKeith M Robinson
May 4, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·Ann L Smiley-OyenQuinn R Emerson
Jul 30, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Georg EbersbachJörg Wissel
May 10, 2005·Brain and Cognition·Paul AparicioRichard B Ivry
Dec 28, 2004·Parkinsonism & Related Disorders·Miguel Fernandez del Olmo, Javier Cudeiro
Apr 14, 2005·Archives of Physical Medicine and Rehabilitation·Abu A QutubuddinWilliam Carne
May 27, 2015·Archives of Physical Medicine and Rehabilitation·Mohan GanesanAnupam Gupta
Dec 11, 2002·Archives of Physical Medicine and Rehabilitation·Annette SterrDieter Schmalohr
Feb 1, 2012·Neurorehabilitation and Neural Repair·Sarah VercruysseAlice Nieuwboer
Feb 21, 2008·Clinical Rehabilitation·Colleen G CanningElke Woodhouse
Mar 11, 2008·Neurorehabilitation and Neural Repair·Somporn Onla-or, Carolee J Winstein
Aug 6, 2004·Clinical Rehabilitation·Heather Gage, Lesley Storey
Jul 22, 2010·Neurorehabilitation and Neural Repair·Máté DöbrössyGuido Nikkhah
Aug 20, 2020·Language and Speech·Fabian TomaschekMichael Ramscar

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