Training-Induced Deactivation of the AT1 Receptor Pathway Drives Autonomic Control and Heart Remodeling During the Transition From the Pre- to Hypertensive Phase in Spontaneously Hypertensive Rats

Circulation Journal : Official Journal of the Japanese Circulation Society
Tassia Santos Rodrigues da CostaLisete C Michelini

Abstract

The effects of hypertension and exercise training (T) on the sequential interplay between renin-angiotensin system (RAS), autonomic control and heart remodeling during the development of hypertension in spontaneously hypertensive rats (SHR), was evaluated.Methods and Results:Time course changes of these parameters were recorded in 4-week-old SHR submitted to a T or sedentary (S) protocol. Wistar Kyoto rats served as controls. Hemodynamic recordings were obtained in conscious rats at experimental weeks 0, 1, 2, 4, and 8. The left ventricle (LV) was collected to evaluate RAS gene and protein expression, cardiomyocytes' hypertrophy and collagen accumulation. Pre-hypertensive SHR exhibited augmented AT1R gene expression; at 5 weeks, they presented with elevated pressure, increased LV angiotensinogen and ACE mRNA expression, followed by sympathoexcitation (from the 8thweek onwards). Marked AT1R protein content, myocytes's hypertrophy, collagen deposition and increased pressure variability were observed in 12-week-old sedentary SHR. In addition to attenuating all these effects, T activated Mas receptor expression augmented parasympathetic modulation of the heart, and delayed the onset and reduced the magnitude, but did not block the ...Continue Reading

References

Apr 1, 1982·Physiological Reviews·B Folkow
Mar 1, 1981·Circulation Research·N C Trippodo, E D Frohlich
May 23, 2002·Hypertension·Alok S PachoriMichael J Katovich
Jun 26, 2007·American Journal of Hypertension·Norihisa ItoToshio Ogihara
Jun 26, 2007·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Hiroyuki TsutsuiKenji Sunagawa
Dec 7, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Jasmina VaragicJavier Díez
Sep 14, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Jiang XuXiao-Ping Yang
Mar 9, 2013·Circulation Journal : Official Journal of the Japanese Circulation Society·Suguru YasuokaTsutomu Imaizumi
Mar 26, 2013·Journal of the American Heart Association·Veronique A Cornelissen, Neil A Smart
Aug 6, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Julia ShanksNeil Herring
Mar 27, 2015·Circulation Journal : Official Journal of the Japanese Circulation Society·Sebastião D SilvaLisete C Michelini
Aug 9, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Gustavo Santos MassonJoseph Francis
Aug 2, 2017·Protein and Peptide Letters·Albena Nunes-SilvaAna Cristina Simoes E Silva
Jan 20, 2018·Physiological Reviews·Robson Augusto Souza SantosMaria Jose Campagnole-Santos
Jun 7, 2018·Physiological Reviews·Steven J ForresterSatoru Eguchi
Oct 26, 2018·Hypertension·Arantxa GonzálezJavier Díez
Mar 9, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Safaa NaielJeffrey G Dickhout
Mar 22, 2019·Nature Reviews. Cardiology·Laura CalvilloGianfranco Parati
Jul 6, 2019·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Wen-Wen PengYan-Xia Pan

❮ Previous
Next ❯

Citations

Nov 25, 2020·Clinical Science·Koichi YamamotoHiromi Rakugi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.