Training voluntary motor suppression with real-time feedback of motor evoked potentials

Journal of Neurophysiology
D S Adnan MajidAdam R Aron

Abstract

Training people to suppress motor representations voluntarily could improve response control. We evaluated a novel training procedure of real-time feedback of motor evoked potentials (MEPs) generated by transcranial magnetic stimulation (TMS) over motor cortex. On each trial, a cue instructed participants to use a mental strategy to suppress a particular finger representation without overt movement. A single pulse of TMS was delivered over motor cortex, and an MEP-derived measure of hand motor excitability was delivered visually to the participant within 500 ms. In experiment 1, we showed that participants learned to reduce the excitability of a particular finger beneath baseline (selective motor suppression) within 30 min of practice. In experiment 2, we performed a double-blind study with 2 training groups (1 with veridical feedback and 1 with matched sham feedback) to show that selective motor suppression depends on the veridical feedback itself. Experiment 3 further demonstrated the importance of veridical feedback by showing that selective motor suppression did not arise from mere mental imagery, even when incentivized with reward. Thus participants can use real-time feedback of TMS-induced MEPs to discover an effective me...Continue Reading

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Citations

Sep 1, 2017·Journal of Neurophysiology·Brandon Wayne CollinsDuane C Button
May 7, 2020·Frontiers in Human Neuroscience·Patricia IzbickiElizabeth L Stegemöller
May 8, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Caroline QuoilinJulie Duque

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