Jun 25, 1999

Trait-like immunological and hematological measures in female rhesus across varied environmental conditions

American Journal of Primatology
A A LillyJ D Higley

Abstract

In this 2-year longitudinal study, 45 2-year-old female rhesus were observed as they were captured and removed from a free-ranging setting (Phase I), single caged for 1 year (Phase II), and housed in small, stable social groups for an additional year (Phase III). During the study, eight blood samples were taken, and hematological, immunological, and hormonal variables were assayed to determine whether 1) any of the measures would exhibit trait-like, inter-individual longitudinal stability, despite fluctuations in population means induced by Phases I, II, and III; 2) plasma concentrations of cortisol, prolactin, and norepinephrine would be lowest in Phase III, and elevated during the periods of acute and chronic stress associated with Phases I and II; and 3) there would be any evidence of immunosuppression associated with Phases I and II. The results suggest that the majority of hematological/immunological variables were trait-like throughout the study in contrast to plasma cortisol, prolactin, and norepinephrine concentrations. Thus, red blood cells, hemoglobin, hematocrit, platelets, mean corpuscular volume and hemoglobin, as well as white blood cells, the absolute number of CD4+ (T-helper/inducer) cells, the absolute number o...Continue Reading

Mentioned in this Paper

PRL
Fluctuation
T-Lymphocyte
Decreased Immunologic Activity [PE]
Depressed - Symptom
Red blood cells, blood product
Suppressor T-Lymphocytes, CD8-Positive
White Blood Cell Count Procedure
Mental Suffering
Differential White Blood Cell Count Procedure

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