Trajectories and risk factors of dementia progression: a memory clinic cohort followed up to 3 years from diagnosis.

International Psychogeriatrics
Trine Holt EdwinAnne-Brita Knapskog

Abstract

Patients with dementia follow different trajectories of progression. We aimed to investigate which factors at the time of diagnosis could predict trajectory group membership. Longitudinal observational study. Specialized memory clinic, Oslo University Hospital in Norway. Patients assessed at the memory clinic, between 12 January 2009 and 31 July 2016, who were registered in the Norwegian Registry of persons assessed for cognitive symptoms (NorCog) and diagnosed with dementia after the baseline examination period (n = 442). The patients were followed up to 3 years, with an average of 3.5 examinations. Clinical Dementia Rating Scale Sum of Boxes (CDR-SB), Mini-Mental State Examination (MMSE), the Consortium to Establish a Registry of Alzheimer's disease (CERAD) 10-item word list delayed recall, the Clock Drawing Test, (CDT) Trail Making Test A (TMT-A), and Neuropsychiatric Inventory Questionnaire (NPI-Q). Based on changes in scores on the CDR-SB, we used group-based trajectory modeling (GBTM) to explore the presence of trajectory groups. Multinomial logistic regression was used to explore whether a set of baseline variables could predict trajectory group membership. Three trajectory groups were identified, one with a slow progres...Continue Reading

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Jun 1, 1982·The British Journal of Psychiatry : the Journal of Mental Science·C P HughesR L Martin
Sep 23, 2000·The Journal of Neuropsychiatry and Clinical Neurosciences·D I KauferS T DeKosky
Sep 24, 2002·JAMA : the Journal of the American Medical Association·Constantine G LyketsosSteven DeKosky
Oct 20, 2005·JAMA : the Journal of the American Medical Association·Lon S SchneiderPhilip Insel
Jun 2, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Murat EmreBruno Dubois
Aug 13, 2008·Archives of Neurology·Sid E O'BryantUNKNOWN Texas Alzheimer's Research Consortium
Mar 3, 2010·Annual Review of Clinical Psychology·Daniel S Nagin, Candice L Odgers
Sep 15, 2010·Dementia and Geriatric Cognitive Disorders·Massimo MusiccoKatie Palmer
Feb 18, 2011·Neurology·M L Gorno-TempiniM Grossman
May 25, 2011·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·JoAnn T TschanzConstantine G Lyketsos
Aug 4, 2011·Brain : a Journal of Neurology·Katya RascovskyBruce L Miller
Jun 15, 2013·International Journal of Geriatric Psychiatry·Brian J MainlandKenneth I Shulman
Mar 10, 2016·Archives of Gerontology and Geriatrics·Maria KrogsethTorgeir Bruun Wyller
May 1, 2016·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Eric JutkowitzRobert L Kane
Oct 19, 2016·Lancet Neurology·Hiral ShahTarun Dua
Jun 29, 2017·Alzheimer's Research & Therapy·Frédéric BlancErik A Sauleau
Sep 5, 2017·Journal of Alzheimer's Disease : JAD·Stéphane P PoulinUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Oct 27, 2017·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Krista L LanctôtBrendon Boot
Dec 20, 2017·Journal of Alzheimer's Disease : JAD·Rannveig Sakshaug EldholmIngvild Saltvedt
May 16, 2018·International Journal of Geriatric Psychiatry·Miriam L HaaksmaJeannie-Marie S Leoutsakos
Aug 15, 2018·Journal of Alzheimer's Disease : JAD·Nienke M E ScheltensUNKNOWN Amsterdam Dementia Cohort, Alzheimer’s Disease Neuroimaging Initiative, German Dementia Competence Network, University of Sa
Dec 18, 2018·Current Opinion in Psychiatry·René J F MelisGraciela Muniz-Terrera
Jul 19, 2019·International Journal of Geriatric Psychiatry·Yuwei WangRené J F Melis
Jul 19, 2019·Dementia and Geriatric Cognitive Disorders·Bjørn Heine StrandGeir Selbaek

❮ Previous
Next ❯

Citations

Jan 20, 2021·International Journal of Geriatric Psychiatry·Trine Holt EdwinAnne-Brita Knapskog
Dec 15, 2020·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Trine Holt EdwinAnne-Brita Knapskog

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: Animal Models

Alzheimer's disease is a neurodegenerative disease which can be studied using various experimental systems. This feed focuses on animal models used for Alzheimer's disease research.