Trajectories of cognitive function in dementia-free subjects: Radiation Effects Research Foundation Adult Health Study

Journal of the Neurological Sciences
Michiko YamadaHideo Sasaki

Abstract

To investigate associations between age, sex, education, and birth cohort and global cognitive decline among a population that would most likely not progress to dementia. A total of 1538 dementia-free subjects aged 60 to 80years in 1992 were followed up through 2011 without dementia occurrence. We assessed cognitive function using the Cognitive Ability Screening Instrument (CASI). Using stepwise-like model selection procedure, we built mixed-effects models for initial cognition and longitudinal cognition. Initial CASI scores for younger age and more years of formal education were higher than those for older and less education. Sex did not show a significant effect. In the longitudinal analysis, cognitive decline became more rapid with increasing age. Sex and education did not modify the degree of deterioration with age. CASI scores were higher for younger cohorts and men due to differences in education levels. Among dementia-free subjects, age is an important predictor of cognitive function level and cognitive decline. Education level affects cognitive function level, but did not affect cognitive decline. The results have implications not only for elucidation of the aging process, but also for reference in dementia screening.

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Citations

Oct 20, 2015·The American Journal of Medicine·Michiko YamadaHideo Sasaki
Nov 15, 2016·Nature Biotechnology·Brady Huggett
Feb 6, 2019·International Journal of Environmental Research and Public Health·Michiko YamadaKevin R Krull
Aug 24, 2016·Current Psychiatry Reports·Guillaume AiragnesFrédéric Limosin
Jan 26, 2021·Journal of Alzheimer's Disease : JAD·Daniel Cuervo-ZanattaClaudia Perez-Cruz
Jan 12, 2021·Frontiers in Public Health·Caroline DupréBienvenu Bongue

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