Trajectories of fatigue in actively treated patients with established rheumatoid arthritis starting biologic DMARD therapy.

RMD Open
Sella A ProvanHilde Berner Hammer

Abstract

To define fatigue trajectories in patients with rheumatoid arthritis (RA) who initiate biological DMARD (bDMARD) treatment, and explore baseline predictors for a trajectory of continued fatigue. One-hundred and eighty-four patients with RA initiating bDMARDs were assessed at 0, 1, 2, 3, 6 and 12 months. Swollen and tender joint counts, patient reported outcomes (PROMs), blood samples and ultrasound examinations were collected at each time point. Fatigue was assessed by the fatigue Numeric Rating Scale (0-10) from the Rheumatoid Arthritis Impact of Disease (RAID) questionnaire. Clinically significant fatigue was predefined as fatigue ≥4. Three trajectories of interest were defined according to level of RAID fatigue: no fatigue (≤3 at 5/6 visits), improved fatigue (≥4 at start, but ≤3 at follow-up) and continued fatigue (≥4 at 5/6 visits). Baseline variables were compared between groups by bivariate analyses, and logistic regression models were used to explore baseline predictors of continued vs improved fatigue. The majority of patients starting bDMARD therapy followed one of three fatigue trajectories, (no fatigue; n=61, improved; n=33 and continued fatigue; n=53). Patients with continued fatigue were more likely to be anti-cit...Continue Reading

References

Jan 23, 2009·Lancet·Lars KlareskogStephen Paget
Jan 27, 2010·Rheumatology·Louise C PollardDavid L Scott
Mar 31, 2011·Rheumatology International·Yousra Ibn YacoubNajia Hajjaj-Hassouni
Jan 22, 2013·Arthritis Care & Research·Stephanie NikolausMart A F J van de Laar
Nov 12, 2015·Arthritis Care & Research·Christin L OlsenHeidi A Zangi

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Citations

Nov 11, 2021·ACR Open Rheumatology·Susanne PetterssonChristina H Opava

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BETA
ELISA

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STATA

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