Trajectories of Physiological Brain Aging and Related Factors in People Aged from 20 to over-80

Journal of Alzheimer's Disease : JAD
Jin San LeeSang Won Seo

Abstract

In this study, we investigated a long-term trajectory of brain aging (from the 20 s to over-80) in cognitively normal (CN) individuals. We further determined whether differences in sex, education years, and apolipoprotein E ε 4 status affect age-related cortical thinning. A total of 2,944 CN individuals who underwent high-resolution (3.0-Tesla) magnetic resonance imaging were included in this study. Cortical thickness was measured using a surface-based method. Multiple linear regression analyses were performed to evaluate age-related cortical thinning and related factors. Compared to those in their 20 s/30 s, participants in their 40 s showed thinning primarily in the medial and lateral frontal and inferior parietal regions, and cortical thinning occurred across most of the cortices with increasing age. Notably, the precuneus, inferior temporal and lateral occipital regions were relatively spared until later in life. Male and lower education years were associated with greater cortical thinning with distinct regional specificity. Our findings provide an important clue to understanding the mechanism of age-related cognitive decline and new strategies for preventing the acceleration of pathological brain aging.

References

Apr 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·R C GurD Berretta
Apr 1, 1994·Current Opinion in Neurobiology·L G Ungerleider, J V Haxby
Mar 1, 1994·Journal of Computer Assisted Tomography·D L CollinsA C Evans
Jun 9, 1998·IEEE Transactions on Medical Imaging·J G SledA C Evans
Mar 22, 2002·NeuroImage·Christopher R GenoveseThomas Nichols
Aug 29, 2002·Nature·Ian J DearyLawrence J Whalley
Oct 23, 2002·Human Brain Mapping·Stephen M Smith
Nov 1, 2003·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·A ArdilaC Gómez
Mar 3, 2004·Annals of Neurology·William E KlunkBengt Långström
Apr 1, 2004·Cerebral Cortex·David H SalatBruce Fischl
Apr 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Michael D GreiciusVinod Menon
Jun 24, 2004·Neurobiology of Aging·Lindsey A LeiglandJeri S Janowsky
Feb 18, 2005·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Marion L KellenbachKaralyn Patterson
Mar 5, 2005·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Teresa E SeemanJack M Guralnik
Apr 27, 2005·Human Brain Mapping·Stuart M GrieveEvian Gordon
Jan 10, 2006·Brain : a Journal of Neurology·Andrea E Cavanna, Michael R Trimble
Sep 27, 2006·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Molly E ZimmermanEvian Gordon
Sep 30, 2006·Brain : a Journal of Neurology·Vivek SinghNoor Jehan Kabani
Feb 3, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·HweeLing LeeCathy J Price
Nov 28, 2008·Annual Review of Psychology·Denise C Park, Patricia Reuter-Lorenz
Jan 20, 2009·Cerebral Cortex·Anders M FjellKristine B Walhovd
Jul 3, 2009·Journal of the International Neuropsychological Society : JINS·Timothy A Salthouse
Jul 9, 2009·Journal of Alzheimer's Disease : JAD·Robyn A HoneaJeffrey M Burns
May 6, 2010·NeuroImage·Madhav ThambisettySusan M Resnick
Oct 1, 2010·Reviews in the Neurosciences·Anders M Fjell, Kristine B Walhovd
Feb 15, 2011·Biological Psychiatry·Lisa T EylerDilip V Jeste
Aug 16, 2011·Brain Topography·Scott M McGinnisBradford C Dickerson
Sep 20, 2011·Journal of the International Neuropsychological Society : JINS·Laura B ZahodneJennifer J Manly
Nov 17, 2011·Ageing Research Reviews·Giuliana KlencklenAndré Dufour
Jan 17, 2012·Neuroradiology·Yawu LiuUNKNOWN AddNeuroMed Consortium
Feb 3, 2012·European Heart Journal·Osvaldo P AlmeidaLeon Flicker
Oct 23, 2012·Journal of Neural Transmission·Christiane S H OedekovenDirk T Leube
Dec 14, 2012·Cerebral Cortex·Anders M FjellUNKNOWN Alzheimer Disease Neuroimaging Initiative
May 7, 2013·Neurobiology of Aging·Anders M FjellUNKNOWN Alzheimer Disease Neuroimaging Initiative
May 21, 2013·Geriatrics & Gerontology International·Leandro FerreiraJosé Carlos Fernandes Galduróz
Jul 30, 2014·Proceedings of the National Academy of Sciences of the United States of America·Daniela WeberAgneta Herlitz

❮ Previous
Next ❯

Citations

Jul 6, 2019·Frontiers in Aging Neuroscience·Jin San LeeSang Won Seo
Dec 25, 2019·Brain Structure & Function·Lídia Vaqué-AlcázarDavid Bartrés-Faz
Feb 3, 2021·Journal of Neuroscience Research·Ana CoelhoNuno Sousa
Mar 29, 2019·NeuroImage. Clinical·Ellen DicksUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Mar 15, 2021·The Science of the Total Environment·Kyung-Duk MinSun-Young Kim

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.