Tramadol for postoperative shivering: a double-blind comparison with pethidine

Anaesthesia and Intensive Care
S BhatnagarS Mishra

Abstract

In most operating and recovery rooms, shivering is controlled by the use of humidifiers, warming blankets, and inhalation of humidified heated oxygen. However, pharmacological control is an effective alternate treatment modality. This randomized, double-blind trial, conducted in 30 ASA Grade 1 or 2 patients, was designed to explore the efficacy of tramadol and pethidine in the treatment of post-anaesthetic shivering. Tramadol is an inhibitor of the re-uptake of serotonin (5-hydroxytryptamine) and norepinephrine in the spinal cord. This facilitates 5-hydroxytryptamine release, which influences thermoregulatory control. We compared the efficacy of tramadol with that of pethidine, presently a widely used drug for the control of shivering. Patients received either tramadol 1 mg/kg or pethidine 0.5 mg/kg intravenously and the grade of shivering, pulse rate, blood pressure and respiratory rate were observed every 10 minutes after injection for one hour Shivering was significantly more likely to have ceased in the tramadol group (12 of 15 versus 4 of 15 cases, P<0.05) at 10 minutes after drug administration and this control was better sustained. No patients receiving tramadol had a recurrence of shivering. It is concluded that intrave...Continue Reading

References

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Citations

Feb 23, 2020·Critical Care Nursing Quarterly·Michael J ArmahizerMehrnaz Pajoumand
Apr 13, 2002·Anaesthesia·S MathewsS Mumtaz
Oct 29, 2004·Clinical Pharmacokinetics·Stefan Grond, Armin Sablotzki
May 27, 2003·Paediatric Drugs·Peter KrankeMartin R Tramèr
Jan 5, 2002·Anesthesia and Analgesia·Swen N PiperJoachim Boldt
Oct 6, 2004·AACN Clinical Issues·Barbara J Holtzclaw
Aug 15, 2012·Critical Care Medicine·Sea Mi ParkAxel J Rosengart
Jan 26, 2008·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·William P Cheshire, Robert D Fealey

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