Tramadol pretreatment enhances ketamine-induced antidepressant effects and increases mammalian target of rapamycin in rat hippocampus and prefrontal cortex.

Journal of Biomedicine & Biotechnology
Chun YangJian-Jun Yang

Abstract

Several lines of evidence have demonstrated that acute administration of ketamine elicits fast-acting antidepressant effects. Moreover, tramadol also has potential antidepressant effects. The aim of this study was to investigate the effects of pretreatment with tramadol on ketamine-induced antidepressant activity and was to determine the expression of mammalian target of rapamycin (mTOR) in rat hippocampus and prefrontal cortex. Rats were intraperitoneally administrated with ketamine at the dose of 10 mg/kg or saline 1 h before the second episode of the forced swimming test (FST). Tramadol or saline was intraperitoneally pretreated 30 min before the former administration of ketamine or saline. The locomotor activity and the immobility time of FST were both measured. After that, rats were sacrificed to determine the expression of mTOR in hippocampus and prefrontal cortex. Tramadol at the dose of 5 mg/kg administrated alone did not elicit the antidepressant effects. More importantly, pretreatment with tramadol enhanced the ketamine-induced antidepressant effects and upregulated the expression of mTOR in rat hippocampus and prefrontal cortex. Pretreatment with tramadol enhances the ketamine-induced antidepressant effects, which is...Continue Reading

References

May 1, 1997·Experimental and Clinical Psychopharmacology·M J DetkeI Lucki
Aug 27, 2005·Experimental Neurology·Maria Noemia Martins de LimaNadja Schröder
Aug 9, 2006·Archives of General Psychiatry·Carlos A ZarateHusseini K Manji
Jan 31, 2009·Drugs of Today·Roy R Reeves, Randy S Burke
Apr 29, 2009·Pharmacology & Therapeutics·Rodrigo Machado-VieiraCarlos A Zarate
Oct 20, 2009·Trends in Pharmacological Sciences·Phil SkolnickRamon Trullas
Nov 10, 2009·Biological Psychiatry·Marije aan het RotSanjay J Mathew
Aug 4, 2010·Archives of General Psychiatry·Nancy DiazgranadosCarlos A Zarate
Sep 10, 2010·Harvard Review of Psychiatry·Carlos ZarateGiacomo Salvadore
Dec 17, 2010·Expert Review of Neurotherapeutics·Kenji Hashimoto
Apr 6, 2011·Experimental and Clinical Psychopharmacology·Justin Barber
Jun 4, 2011·Progress in Neuro-psychopharmacology & Biological Psychiatry·Courtney S JerniganBeata Karolewicz
Jul 5, 2011·The American Journal of Psychiatry·Magdalena C DenkChristoph W Turck
Sep 13, 2011·Neuropharmacology·Ronald S DumanGeorge Aghajanian

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Citations

Oct 4, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ana M Gonzalez-AnguloRazelle Kurzrock
Mar 4, 2014·Life Sciences·Helena M AbelairaJoão Quevedo
Nov 28, 2015·British Journal of Clinical Pharmacology·Zuleide M IgnácioJoão Quevedo
Dec 10, 2017·Naunyn-Schmiedeberg's Archives of Pharmacology·Morgana MorettiAna Lúcia S Rodrigues
May 23, 2020·Therapeutic Advances in Psychopharmacology·Dmitriy MatveychukSerdar M Dursun

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Statistical Product for the Social Sciences ( SPSS
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