Tramadol reduces the sweating, vasoconstriction, and shivering thresholds

Anesthesia and Analgesia
Jan De WitteA R Bjorksten

Abstract

The analgesic tramadol inhibits the neuronal reuptake of norepinephrine and 5-hydroxytryptamine, facilitates 5-hydroxytryptamine release, and activates mu-opioid receptors. Each of these actions is likely to influence thermoregulatory control. We therefore tested the hypothesis that tramadol inhibits thermoregulatory control. Eight volunteers were evaluated on four study days, on which they received no drugs, tramadol 125 mg, tramadol 250 mg, and tramadol 250 mg with naloxone, respectively. Skin and core temperatures were gradually increased until sweating was observed and then decreased until vasoconstriction and shivering were detected. The core temperature triggering each response defined its threshold. Tramadol decreased the sweating threshold by -1.03 +/- 0.67 degrees C microgram-1.mL (r2 = 0.90 +/- 0.12). Tramadol also decreased the vasoconstriction threshold by -3.0 +/- 4.0 degrees C microgram-1.mL (r2 = 0.94 +/- 0.98) and the shivering threshold by -4.2 +/- 4.0 degrees C microgram-1.mL(r2 = 0.98 +/- 0.98). The sweating to vasoconstriction interthreshold range nearly doubled from 0.3 +/- 0.4 degree C to 0.7 +/- 0.6 degree C during the administration of large-dose tramadol (P = 0.04). The addition of naloxone only partial...Continue Reading

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Citations

Dec 10, 2003·Best Practice & Research. Clinical Anaesthesiology·Chiharu Negishi, Rainer Lenhardt
May 6, 2006·British Journal of Anaesthesia·R KomatsuD Sessler
Jan 31, 2002·Anesthesiology·Jan De Witte, Daniel I Sessler
Oct 3, 2006·Current Opinion in Anaesthesiology·E P Horn
Oct 4, 2006·Current Opinion in Anaesthesiology·P J le Roux, J F Coetzee
Jun 26, 2009·Critical Care Medicine·Daniel I Sessler
Jul 11, 2009·The Neurologist·Julius Gene S Latorre, David M Greer
Oct 26, 2005·Anesthesia and Analgesia·Ryu KomatsuRainer Lenhardt
May 21, 2014·Saudi Journal of Anaesthesia·Semsettin BozgeyikBerna Kaya Ugur
Feb 22, 2012·Journal of Anaesthesiology, Clinical Pharmacology·Sukhminder Jit Singh BajwaSs Parmar
Jan 7, 2014·The Journal of Surgical Research·PeiWen ZhouZhangGang Xue
May 23, 2008·Best Practice & Research. Clinical Anaesthesiology·Andrea Kurz
Jun 10, 2015·Experimental Neurology·Ziping HanXunming Ji

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