Trandolapril decreases prevalence of ventricular ectopic activity in middle-aged SHR

Circulation
B ChevalierB Swynghedauw

Abstract

Although severe arrhythmias are still a major problem in patients with left ventricular hypertrophy (LVH), the relationship between ventricular remodeling and its regression or prevention, and the prevalence of ventricular premature beats (VPB) or more sustained arrhythmias are still poorly explored in hypertensive heart disease. Holter monitoring was used to quantify supraventricular premature beats and VPB and heart rate (HR) in middle-aged spontaneously hypertensive rats (SHR) and Wistar rats treated for 3 months with trandolapril (ACE inhibitor, 0.3 mg/kg per day). Hypertrophy and fibrosis were morphometrically determined. Statistical analysis was performed with the use of simple regression and multivariate data analysis (cluster and correspondence analysis). SHR have higher cardiac mass and fibrosis, more VPB, and a decreased HR. Cluster analysis demonstrated that trandolapril was only effective in SHR. Trandolapril significantly reduced cardiac hypertrophy, fibrosis, and VPB incidence and increased the HR. Simple regression analysis showed that VPB incidence correlated to both hypertrophy and fibrosis. Correspondence analysis evidenced a strong correlation between hypertrophy, fibrosis, and VPB, but only for severe hypert...Continue Reading

References

Jan 1, 1991·Journal of Cardiovascular Pharmacology·J M McLenachan, H J Dargie
May 1, 1991·Journal of the American College of Cardiology·J K GhaliY L Liao
Dec 1, 1991·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·M MalerbaE Agabiti-Rosei
Aug 10, 1989·The New England Journal of Medicine·UNKNOWN Cardiac Arrhythmia Suppression Trial (CAST) Investigators
Jul 1, 1971·Circulation·B Lown, M Wolf
Jul 1, 1984·The American Journal of Medicine·F H MesserliE D Frohlich
Dec 1, 1984·The American Journal of Cardiology·R J MyerburgA Castellanos
Apr 1, 1993·American Journal of Hypertension·R A González-FernándezJ E Lugo
Jul 1, 1994·Journal of Molecular and Cellular Cardiology·C G BrillaK T Weber
Mar 1, 1994·Journal of Molecular and Cellular Cardiology·K T WeberJ P Cleutjens

❮ Previous
Next ❯

Citations

Jan 1, 1997·Cardiovascular Drugs and Therapy·B SwynghedauwF Carré
Mar 2, 2002·Autonomic Neuroscience : Basic & Clinical·José Dias da Silva ValdoNicola Montano
Feb 2, 2011·Journal of Cardiovascular Pharmacology·Vincent ChanLindsay Brown
Feb 28, 2001·Proceedings of the National Academy of Sciences of the United States of America·P MenetonF Alhenc-Gelas
Feb 24, 2001·Journal of Hypertension·M G Hennersdorf, B E Strauer
May 9, 2002·Expert Opinion on Investigational Drugs·Bernard Swynghedauw
Sep 1, 2015·Canadian Journal of Physiology and Pharmacology·Veronika Ledvényiová-FarkašováTana Ravingerová
Aug 16, 2005·Journal of the American College of Cardiology·Frank BogunFred Morady
Sep 10, 2002·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·V J Dias da SilvaR Fazan
Jan 29, 1999·Physiological Reviews·B Swynghedauw
Sep 29, 2000·American Journal of Physiology. Heart and Circulatory Physiology·P TrouveD Charlemagne
Apr 12, 2002·Physiological Genomics·Stephen B HarrapLeanne M D Delbridge
Dec 5, 2016·Naunyn-Schmiedeberg's Archives of Pharmacology·Luiz Fernando Rodrigues JuniorJosé Hamilton Matheus Nascimento
Mar 7, 2021·Journal of Human Hypertension·R NadarajahM H Tayebjee
Dec 1, 1996·Journal of Cardiac Failure·B SwynghedauwS Besse

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.

Cardiac Remodeling

Cardiac remodeling in response to a myocardial infarction is characterized by progressive ventricular dilatation, cardiac hypertrophy, fibrosis, and deterioration of cardiac performance. Discover the latest research on Cardiac Remodeling here.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Cardiomegaly

Cardiomegaly, known as an enlarged heart, is a multifactorial disease with different pathophysiological mechanisms. Hypertension, pregnancy, exercise-induced and idiopathic causes are some mechanisms of cardiomegaly. Discover the latest research of cardiomegaly here.