Tranexamic acid: a review of its use in the management of menorrhagia

Drugs
Keri Wellington, Antona J Wagstaff

Abstract

Tranexamic acid (Transamin), Cyklokapron, Exacyl, Cyklo-f) is a synthetic lysine derivative that exerts its antifibrinolytic effect by reversibly blocking lysine binding sites on plasminogen and thus preventing fibrin degradation. In a number of small clinical studies in women with idiopathic menorrhagia, tranexamic acid 2-4.5 g/day for 4-7 days reduced menstrual blood loss by 34-59% over 2-3 cycles, significantly more so than placebo, mefenamic acid, flurbiprofen, etamsylate and oral luteal phase norethisterone at clinically relevant dosages. Intrauterine administration of levonorgestrel 20 microg/day, however, produced the greatest reduction (96% after 12 months) in blood loss; 44% of patients treated with levonorgestrel developed amenorrhoea. Tranexamic acid 1.5 g three times daily for 5 days also significantly reduced menstrual blood loss in women with intrauterine contraceptive device-associated menorrhagia compared with diclofenac sodium (150 mg in three divided doses on day 1 followed by 25 mg three times daily on days 2-5) or placebo. Tranexamic acid, mefenamic acid, etamsylate, flurbiprofen or diclofenac sodium had no effect on the duration of menses in the studies that reported such data. In a large noncomparative, no...Continue Reading

Associated Clinical Trials

References

May 1, 1991·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·J M Higham, R W Shaw
Aug 1, 1991·British Journal of Obstetrics and Gynaecology·A CoulterA Tulloch
Oct 1, 1991·American Journal of Hematology·G SoslauI Brodsky
Jun 1, 1989·Baillière's Clinical Obstetrics and Gynaecology
Jun 1, 1989·Baillière's Clinical Obstetrics and Gynaecology·I T Cameron
Apr 1, 1987·European Journal of Obstetrics, Gynecology, and Reproductive Biology·C J DockerayJ Bonnar
Aug 23, 1974·European Journal of Clinical Pharmacology·O ErikssonM Schannong
Oct 24, 1970·British Medical Journal·S T CallenderE Cope
Dec 19, 1970·British Medical Journal·K E Shuttleworth
Jan 1, 1995·International Journal of Technology Assessment in Health Care·A CoulterM C Rees
May 1, 1995·British Journal of Obstetrics and Gynaecology·J T PrestonS K Smith
Jul 1, 1996·Anesthesia and Analgesia·L Shore-LessersonM A Ergin
Jan 9, 1998·British Journal of Obstetrics and Gynaecology·R Garry
Jul 23, 1998·The New England Journal of Medicine·P M Mannucci
Jan 5, 1999·Haemophilia : the Official Journal of the World Federation of Hemophilia·Y L OngE E Mayne
Jul 20, 1999·American Journal of Obstetrics and Gynecology·K L Dardano, R T Burkman
Aug 15, 2000·Baillière's Best Practice & Research. Clinical Obstetrics & Gynaecology·G A Irvine, I T Cameron
Feb 24, 2001·BJOG : an International Journal of Obstetrics and Gynaecology·A StewartW Phillips
Jan 15, 2002·European Journal of Obstetrics, Gynecology, and Reproductive Biology·U H Winkler
Aug 2, 2002·Anesthesiology·Noreen P DowdJohn Butterworth
Oct 31, 2002·The Australian & New Zealand Journal of Obstetrics & Gynaecology·S Park, C M Farquhar

❮ Previous
Next ❯

Citations

Apr 19, 2013·Archives of Gynecology and Obstetrics·Azita GoshtasebiSamira Behboudi Gandevani
Jul 16, 2010·Pharmacy World & Science : PWS·Selene ImbesiSebastiano Gangemi
Jul 15, 2009·Journal de gynécologie, obstétrique et biologie de la reproduction·O Graesslin, E Derniaux
Apr 5, 2005·Clinical Obstetrics and Gynecology·Jamie E Siegel
Mar 21, 2007·Obstetrical & Gynecological Survey·Anita L Nelson, Stephanie B Teal
Jun 28, 2011·Menopause : the Journal of the North American Menopause Society·JoAnn V Pinkerton
Sep 8, 2012·International Journal of Women's Health·Henri Leminen, Ritva Hurskainen
Dec 18, 2013·European Journal of Pharmacology·Hitoshi KakiuchiKensuke Orito
Apr 27, 2007·Southern Medical Journal·Sara B Fazio, Amy N Ship
May 3, 2014·Advanced Emergency Nursing Journal·Abby M BaileyKyle A Weant
Feb 14, 2014·Archives of Orthopaedic and Trauma Surgery·Jerry Yongqiang ChenSeng Jin Yeo
Nov 25, 2014·American Journal of Veterinary Research·Hitoshi KakiuchiKensuke Orito
Sep 23, 2010·Obstetrics and Gynecology·Andrea S LukesGary A Shangold
Sep 1, 2012·Women's Health·Andrea S LukesTammie L Adomako
Nov 4, 2011·Journal of Women's Health·Sonal ChaudhryMichelle Warren
Mar 21, 2012·Journal of Women's Health·Ken MuseTammie L Adomako
Sep 22, 2006·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Bojan Vujkovac, Miso Sabovic
Apr 1, 2010·Journal of Bronchology & Interventional Pulmonology·Eduardo Márquez-MartínFrancisco Rodríguez-Panadero
Oct 31, 2006·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·A KriplaniS Diwakar
Jan 24, 2009·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Leila SekhavatAtefah Dehghani Tafti
Nov 23, 2011·The Journal of Dermatological Treatment·Hyun Hee ChoJong Hee Lee
Sep 6, 2012·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Efthimios DeligeoroglouGeorge Creatsas
Feb 8, 2011·Expert Opinion on Pharmacotherapy·Panagiotis Peitsidis, Rezan A Kadir
Jul 28, 2012·Current Medical Research and Opinion·Kenneth E Fox
Mar 28, 2008·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Ian S FraserAndrea S Lukes
Feb 28, 2008·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Ian S FraserAndrea S Lukes
Nov 19, 2015·Annals of Neurology·Irene LeckerBeverley A Orser
Apr 2, 2013·The Journal of Arthroplasty·Tyler C WindJoseph T Moskal
Nov 10, 2012·Emergency Medicine Clinics of North America·Angela R Cirilli, Stephen J Cipot
Jan 23, 2016·Best Practice & Research. Clinical Obstetrics & Gynaecology·Banafsheh N KashaniFelice Petraglia
Aug 21, 2012·Nursing for Women's Health·Jeanne M Wilton
Jan 26, 2011·Thrombosis Research·Claire S Philipp
Jun 8, 2010·Otolaryngologic Clinics of North America·Frank W VirginBradford A Woodworth
Aug 10, 2015·American Journal of Obstetrics and Gynecology·Linda D Bradley, Ndeye-Aicha Gueye
Jul 14, 2006·Mayo Clinic Proceedings·Catherine R Weiler, Richard G van Dellen
May 15, 2007·European Journal of Obstetrics, Gynecology, and Reproductive Biology·G S CaglarA Haberal
Jun 28, 2005·American Journal of Hematology·Jody L Kujovich
Jul 13, 2006·Haemophilia : the Official Journal of the World Federation of Hemophilia·C A LeeUNKNOWN UK Haemophilia Centre Doctors' Organization
Jul 9, 2013·British Journal of Haematology·Menaka PaiRonald Barr
Jan 11, 2012·Acta Obstetricia Et Gynecologica Scandinavica·Becky Naoulou, Ming C Tsai
Feb 14, 2006·Contraception·Vorapong PhupongSurasak Taneepanichskul
Sep 6, 2005·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Pietro LittaAntonio Ambrosini

❮ Previous
Next ❯

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