Abstract
Haemostatic balance shifts towards pro-coagulation during infection. Plasminogen, a key molecule of fibrinolysis, may play an important role in the pathogenesis of staphylococcal infections. In the present study, we assessed the impact of inhibition of plasminogen activation by tranexamic acid on the course of staphylococcal sepsis and septic arthritis in mice. We found significantly down-regulated plasmin activity and increased D-dimer levels in the blood from the mice with staphylococcal sepsis. Treatment with tranexamic acid significantly increased the severity and mortality of staphylococcal infection. In addition, tranexamic acid reduced the survival rate in a murine model for staphylococcal enterotoxin A-induced death. The aggravation of diseases by tranexamic acid was due neither to the pro-inflammatory cytokine network, nor to impairment of bacterial clearance. Modulation of fibrinolysis, either by supplement of fibrinolytic molecules (tissue plasminogen activator or plasmin) or by fibrinogen depletion, did not reduce the mortality of staphylococcal sepsis. In conclusion, we report that treatment with tranexamic acid led to distinct aggravation of staphylococcal septic arthritis and sepsis in mice, suggesting the clinic...Continue Reading
References
Aug 1, 1991·Infection and Immunity·T BremellA Tarkowski
Nov 1, 1990·Arthritis and Rheumatism·T BremellA Tarkowski
Mar 29, 1990·The New England Journal of Medicine·P BertozziH A Chapman
Oct 1, 1988·European Journal of Immunology·M HelleL A Aarden
Jan 1, 1973·British Journal of Haematology·S SilbermanH C Kwaan
Jun 1, 1994·Infection and Immunity·T BremellA Tarkowski
Jan 1, 1993·Annual Review of Cell Biology·K J Tracey, A Cerami
Mar 1, 1996·Shock·A KidokoroY Yagi
Aug 1, 1996·American Journal of Respiratory Cell and Molecular Biology·N KhalilH Yacyshyn
Feb 20, 1999·Infection and Immunity·B G StilesS A Grove
Aug 14, 2001·Infection and Immunity·A NordstrandS Bergström
Jan 24, 2002·Circulation·Ilka OttFranz-Josef Neumann
Jul 3, 2002·The Journal of Biological Chemistry·Ladislav BurysekThomas Simmet
Jun 30, 2004·American Journal of Hematology·Kazuhiro OkabayashiKazuo Maruyama
Jul 13, 2004·Advances in Immunology·Christopher J CzuraKevin J Tracey
Aug 31, 2004·Science·Hongmin SunDavid Ginsburg
Oct 16, 2004·Chest·Jose M Querol-RibellesIsidoro Martinez
Jul 5, 2005·The Journal of Infectious Diseases·Tao JinAndrej Tarkowski
Jun 1, 2007·The New England Journal of Medicine·Pier Mannuccio Mannucci, Marcel Levi
Jul 21, 2007·The American Journal of Pathology·Haiwang TangFlorea Lupu
Mar 4, 2008·Arthritis and Rheumatism·Yongzhi GuoTor Ny
Citations
Jul 12, 2011·The Journal of Infectious Diseases·Ying FeiTao Jin
Jun 27, 2013·The Journal of Infectious Diseases·Jakub KwiecinskiTao Jin
Jan 24, 2013·Infection and Immunity·Jakub KwiecinskiTao Jin
Jan 13, 2015·Transfusion Medicine Reviews·Dominik F Draxler, Robert L Medcalf
Feb 13, 2015·Blood·Nuha HijaziAbd Al-Roof Higazi
Aug 9, 2016·The Journal of Arthroplasty·Qunn Jid LeeYiu Chung Wong
Feb 24, 2017·Knee Surgery & Related Research·Qunn Jid LeeYiu Chung Wong
May 3, 2018·Medicine·Peipei GuoLiming Cheng
Oct 29, 2017·Journal of Orthopaedic Surgery and Research·Lu-Kai ZhangZheng-Rui Fan
May 30, 2019·Journal of Neurotrauma·Dominik F DraxlerRobert L Medcalf
Dec 6, 2018·Current Drug Targets·Benjamin J BuckleyMarie Ranson
Jan 1, 2020·PloS One·Yzabella Alves Campos NogueiraErich Vinicius De Paula
Jul 1, 2014·Spine·Jason M CuellarThomas J Errico
Jul 4, 2020·Scientific Reports·Anders JarnebornTao Jin
Nov 1, 2016·Journal of Thrombosis and Haemostasis : JTH·K VadivelS P Bajaj
Mar 28, 2020·Asian Spine Journal·Moti KramerLayalee Abu Nasser
Nov 1, 2020·Medicine·Changjiao SunHuadong Yang
Apr 1, 2021·Communications Biology·Majd MohammadTao Jin
Apr 21, 2021·Seminars in Thrombosis and Hemostasis·Julie Brogaard Larsen, Anne-Mette Hvas
Mar 30, 2019·Immunology Letters·Sahin SultanaBiswadev Bishayi