Tranexamic acid for hemostasis in the surgical treatment of metastatic tumors of the spine

Spine
Drew A BednarForough Farroukhyar

Abstract

This is a retrospective study of sequential cohorts. To assess the efficacy of tranexamic acid in decreasing operative blood loss and the need for intraoperative transfusion in metastatic spine surgery. Significant published data have established the efficacy of antifibrinolytic drugs in limiting surgical bleeding during heart surgery and total joint replacement. One study in scoliosis suggested benefit in spine surgery as well. During a 6-month trial period, 14 patients with spine cancer undergoing palliative intralesional tumor excision and concomitant instrumentation to stabilize the spine in the hands of a single surgeon were administered tranexamic acid intraoperatively in the attempt to minimize operative blood loss. They were then compared to the immediately preceding 14 patients. Estimated operative blood loss was 1385 mL in the study group treated with tranexamic acid and 1815 mL in controls not receiving the drug, and was not found to be significantly decreased in this study. Control of operative bleeding in metastatic spine surgery can be problematical. Optimum protocol might include routine preoperative angiographic tumor embolization to decrease lesion vascularity in all cases, but angiography is not without risk. ...Continue Reading

Associated Clinical Trials

Jun 3, 2013·Jose Rodriguez, MD, Jose Rodriguez, MD

References

Nov 1, 1996·The Journal of Bone and Joint Surgery. British Volume·J P HowesA T Cohen
Jun 17, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J P KavoliusM S Brady
Jul 23, 1998·The New England Journal of Medicine·P M Mannucci
Feb 16, 2000·British Journal of Anaesthesia·A J JansenK Jochmans
Sep 30, 2000·Archives of Orthopaedic and Trauma Surgery·K IdoS Kuriyama
Oct 26, 2000·Anesthesia and Analgesia·G EkbäckU Schött
Jun 29, 2001·Anesthesia and Analgesia·D T NeilipovitzW M Splinter
Dec 21, 2002·Anaesthesia·J C Watts
Jan 8, 2004·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Erik LemayAlain Roy
Jun 9, 2004·Critical Reviews in Oncology/hematology·Marcello De Cicco
Jun 10, 2004·The Journal of Arthroplasty·Narendra Garneti, Jeremy Field

❮ Previous
Next ❯

Citations

Oct 3, 2007·Annals of Surgical Oncology·Hamid Namazi, Kamran Mozaffarian
Aug 3, 2011·Orthopedic Reviews·Christian Wedemeyer, Max Daniel Kauther
Aug 13, 2011·Journal of Neurosurgical Anesthesiology·Majid R FarrokhiKamal Akbari
Nov 9, 2010·Journal of Clinical Anesthesia·Michael R AndersonMeg A Rosenblatt
Apr 16, 2016·Anaesthesia Critical Care & Pain Medicine·Claire DupuisSouhayl Dahmani
Aug 28, 2015·The Journal of Foot and Ankle Surgery : Official Publication of the American College of Foot and Ankle Surgeons·Bing XieDa-peng Zhou
Nov 4, 2008·The Journal of Bone and Joint Surgery. American Volume·J Brian GillDu Feng
Apr 22, 2016·Global Spine Journal·Sebastian F WinterMichael G Fehlings
Nov 10, 2017·Journal of Pediatric Orthopedics·Daniel J JohnsonSteven M Frank
Aug 14, 2021·Journal of Neurosurgery. Spine·Zach PenningtonDaniel M Sciubba

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.