Tranexamic acid in life-threatening military injury and the associated risk of infective complications

The British Journal of Surgery
C J LewisJames D Ross

Abstract

Tranexamic acid (TXA) has been shown to reduce mortality from severe haemorrhage. Although recent data suggest that TXA has anti-inflammatory properties, few analyses have investigated the impact of TXA on infectious complications in injured patients. The aim was to examine the association between TXA administration and infection risk among injured military personnel. Patients who received TXA were matched by Injury Severity Score with patients who did not receive TXA. Conditional logistic regression was used to examine risk factors associated with infections within 30 days. A Cox proportional analysis evaluated risk factors in a time-to-first-infection model. A total of 335 TXA recipients were matched with 626 patients who did not receive TXA. A greater proportion of TXA recipients had an infection compared with the comparator group (P < 0·001). Univariable analysis estimated an unadjusted odds ratio (OR) of 2·47 (95 per cent c.i. 1·81 to 3·36) for the association between TXA and infection risk; however, TXA administration was not significant in multivariable analysis (OR 1·27, 0·85 to 1·91). Blast injuries, intensive care unit (ICU) admission, and receipt of 10 units or more of blood within 24 h after injury were independentl...Continue Reading

References

Jun 1, 1972·The Journal of Clinical Investigation·D CollenP Wallén
Jan 1, 1981·European Journal of Clinical Pharmacology·A PilbrantJ Vessman
Nov 1, 1995·Annals of Epidemiology·S Linn
Jun 12, 2009·The Journal of Trauma·Clinton K MurrayDuane R Hospenthal
Jan 5, 2011·Thrombosis Research·Jari Petäjä
Oct 19, 2011·Archives of Surgery·Jonathan J MorrisonMark J Midwinter
Mar 29, 2012·Transfusion·Rachael P JackmanPhilip J Norris
May 9, 2012·Journal of Leukocyte Biology·Tatiana SyrovetsThomas Simmet
Jun 30, 2012·The Journal of Trauma and Acute Care Surgery·Philip J BelmontAndrew J Schoenfeld
Nov 13, 2012·Archives of Gynecology and Obstetrics·Mehmet B SentürkPınar Yildiz
Jul 28, 2013·The Journal of Trauma and Acute Care Surgery·Andrew J SchoenfeldPhilip J Belmont

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Citations

May 28, 2019·The Western Journal of Emergency Medicine·Simranjeet BenipalDaniel K Nishijima
Mar 17, 2020·The Breast Journal·Kush Raj LohaniAnita Dhar
Jun 5, 2018·Surgical Infections·Amy C WeintrobDavid R Tribble
Nov 30, 2019·Military Medicine·Christian Coles, Martin G Ottolini

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