Tranexamic acid increases hemoglobin and ferritin levels in women with heavy menstrual bleeding

Journal of Women's Health
Ken MuseTammie L Adomako

Abstract

Heavy menstrual bleeding (HMB) is the most common cause of iron deficiency anemia (IDA) in women. A novel, modified-release oral formulation of tranexamic acid (TA) designed to reduce gastrointestinal side effects was approved recently for treatment of HMB. We assessed improvements in objective laboratory measures of IDA in women with self-reported HMB who received long-term TA therapy. Women enrolled in a long-term, open-label, multicenter study self-medicated with TA 3.9 g/day administered as 1.3 g orally up to three times daily for 5 days/menstrual cycle for 27 cycles. Oral iron therapy was required if serum hemoglobin (Hgb) levels decreased to <11 g/dL. A total of 723 women (mean age 38.3 years) were included in the intent-to-treat (ITT) population. Significant increases in mean serum Hgb and ferritin were observed throughout the study (p<0.01). Among 191 patients with low Hgb (<12 g/dL) at baseline, mean serum Hgb increased by ≥0.71 g/dL after the third cycle and all subsequent assessments (p<0.001). After 3 and 27 cycles, 34.1% and 45.7%, respectively, of patients with low Hgb at baseline shifted to within normal range, respectively. Among 233 patients with low ferritin (<10 ng/mL) at baseline, mean serum ferritin increas...Continue Reading

References

Mar 1, 1990·The American Journal of Medicine·G H GuyattR Meyer
Jan 1, 1966·Acta Obstetricia Et Gynecologica Scandinavica·L HallbergG Rybo
May 1, 1995·British Journal of Obstetrics and Gynaecology·J T PrestonS K Smith
Mar 1, 1995·The Medical Clinics of North America·P I WathenC A Witz
Jan 15, 2002·European Journal of Obstetrics, Gynecology, and Reproductive Biology·U H Winkler
Jun 27, 2003·Drugs·Keri Wellington, Antona J Wagstaff
May 30, 2007·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Zhimei LiuRobert W Dubois
Aug 21, 2009·Archives of Gynecology and Obstetrics·Sérgio Simões de SouzaAgnaldo Lopes Silva Filho
Sep 23, 2010·Obstetrics and Gynecology·Andrea S LukesGary A Shangold

❮ Previous
Next ❯

Citations

Jul 9, 2013·British Journal of Haematology·Menaka PaiRonald Barr
May 24, 2016·Obstetrics and Gynecology Clinics of North America·Jody L Kujovich
May 4, 2015·American Journal of Obstetrics and Gynecology·Anita L Nelson, Julia J Ritchie
Jul 20, 2012·The Annals of Pharmacotherapy·Sandra L Hrometz
Apr 12, 2018·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Mahdis NaafeAbolfazl Mohammadbeigi

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
contraception

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.