Tranexamic acid induces kaolin intake stimulating a pathway involving tachykinin neurokinin 1 receptors in rats

European Journal of Pharmacology
Hitoshi KakiuchiKensuke Orito

Abstract

Tranexamic acid suppresses post-partum haemorrhage and idiopathic menorrhagia through its anti-fibrinolytic action. Although it is clinically useful, it is associated with high risks of side effects such as emesis. Understanding the mechanisms underlying tranexamic acid-induced emesis is very important to explore appropriate anti-emetic drugs for the prevention and/or suppression of emesis. In this study, we examined the receptors involved in tranexamic acid-induced kaolin intake in rats, which reflects the drug's clinical emetogenic potential in humans. Further, we examined the brain regions activated by administration of tranexamic acid and elucidated pivotal pathways of tranexamic acid-induced kaolin intake. We examined the effects of ondansetron, a 5-hydroxytryptamine 3 receptor antagonist, domperidone, a dopamine 2 receptor antagonist, and aprepitant, a tachykinin neurokinin 1 (NK1) receptor antagonist, on tranexamic acid-induced kaolin intake in rats. Then, we determined the brain regions that showed increased numbers of c-Fos immunoreactive cells. Finally, we examined the effects of an antagonist(s) that reduced tranexamic acid-induced kaolin intake on the increase in c-Fos immunoreactive cells. Aprepitant significantly ...Continue Reading

References

Sep 1, 1972·Hormones and Behavior·M B ter Haar
Aug 1, 1993·Pharmacology, Biochemistry, and Behavior·N TakedaT Matsunaga
May 20, 1997·European Journal of Pharmacology·N M RupniakR J Hargreaves
May 30, 1998·Journal of Neuroscience Methods·T SaitoT Nemoto
Jan 7, 1999·European Journal of Pharmacology·M MinamiK Kisara
Apr 11, 2003·Journal of Pharmacological Sciences·Ryo SaitoHiro-O Kamiya
Jun 27, 2003·Drugs·Keri Wellington, Antona J Wagstaff
Aug 2, 2006·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Ryo Saito, Yukio Takano
Nov 10, 2006·Autonomic Neuroscience : Basic & Clinical·Charles C HornArun Chaudhury
Nov 18, 2006·European Journal of Pharmacology·Kouichi YamamotoAtsushi Yamatodani
Jul 17, 2009·BMC Pregnancy and Childbirth·Pili FerrerHaleema Shakur
May 11, 2010·Journal of Pharmacological and Toxicological Methods·Kouichi YamamotoAtsushi Yamatodani
May 5, 2011·European Journal of Pharmacology·Yoko TatsushimaRyozo Oishi
Aug 31, 2011·The Journal of Pharmacology and Experimental Therapeutics·Vinita R Batra, Lisa M Schrott
Sep 15, 2011·British Journal of Pharmacology·Nathalie Percie du SertPaul Lr Andrews
May 9, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Samo Ribarič
May 23, 2012·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Tetsuo OgawaSeiji Shioda

❮ Previous
Next ❯

Citations

Nov 25, 2014·American Journal of Veterinary Research·Hitoshi KakiuchiKensuke Orito
Sep 27, 2018·American Journal of Veterinary Research·Katie E OsekavageAmie Koenig

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Thyroiditis

Autoimmune thyroiditis is an inflammatory disease of thyroid gland due to autoimmune responses leading to lymphocytic infiltration of the gland. It is characterized by the presence of circulating thyroid antigen-specific T-cells and thyroid autoantibodies. Discover the latest research on autoimmune thyroiditis here.

Related Papers

European Journal of Pharmacology
Yoko TatsushimaR Oishi
Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer
Karin JordanMASCC/ESMO
The British Journal of Cancer. Supplement
B Costall, R J Naylor
© 2021 Meta ULC. All rights reserved