Tranexamic acid is effective for blood management in open-wedge high tibial osteotomy

Orthopaedics & Traumatology, Surgery & Research : OTSR
Kang-Il KimSeong Hae Bae

Abstract

There has been paucity in literature regarding the blood-sparing effect of TXA after high tibial osteotomy (HTO). The purpose of this study is to determine the efficacy of tranexamic acid (TXA) with regard to its blood-sparing effects in open-wedge HTO, and to assess thromboembolic complications in patients undergoing open-wedge HTO with or without the use of TXA. The intravenous TXA would reduce postoperative blood loss and transfusion requirements without increasing thromboembolic complications in open-wedge HTO. From March 2011 to December 2016, medial open-wedge HTO was performed in 150 consecutive knees with varus gonarthrosis. The mean age at the time of surgery was 55.3±5.0 years. TXA was intravenously used in the latter 75 knees (TXA group), and the group was retrospectively compared with the former 75 knees without use of TXA (control group). Outcome measures were postoperative hemoglobin drop, drain amount, total estimated blood loss, transfusion requirements, and incidence of thromboembolic complications. The use of TXA led to a significant decrease in hemoglobin drop (p<0.001) and drain amount (p=0.025). Total estimated blood loss was lower in the TXA group than in the control group (p<0.001). Two knees in the contr...Continue Reading

Citations

Jul 28, 2020·Archives of Orthopaedic and Trauma Surgery·Jianlong NiZhibin Shi
Nov 19, 2020·BioMed Research International·De-Sheng ChenCai-Hong Feng
Nov 13, 2020·Journal of Orthopaedic Surgery and Research·Zheng LiLei Ding
Jun 13, 2021·Journal of Orthopaedic Surgery and Research·Jimin MaQiang Wang
Oct 27, 2021·Archives of Orthopaedic and Trauma Surgery·Wolf PetersenMartin Häner

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