PMID: 7537081Jan 1, 1995Paper

Tranilast inhibits collagen synthesis in normal, scleroderma and keloid fibroblasts at a late passage culture but not at an early passage culture

Journal of Dermatological Science
H YamadaT Nishikawa

Abstract

We have previously reported that tranilast, an anti-allergic agent, specifically suppresses collagen synthesis in normal skin fibroblasts and to a greater extent in keloid fibroblasts. We found in this study that the specific suppression of collagen synthesis by tranilast was limited to the fibroblasts with a high passage number (passage 8-10). In normal skin fibroblasts with a low passage number (passage 1-2), tranilast exerted no significant effect on collagen synthesis. This was also observed with scleroderma and keloid fibroblasts. This result suggests that inhibition of collagen by tranilast will be dependent on in vitro cellular aging and that serial cell passages result in the loss of the cell phenotype resistant to tranilast effect.

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Citations

Apr 2, 2009·Nature Reviews. Rheumatology·John Varga, Boris Pasche
Oct 30, 2010·Medical Hypotheses·Kamran MansouriMaryam Keshavarz
Jan 31, 2014·Fibrogenesis & Tissue Repair·Kristy SwiderskiGordon S Lynch
Dec 3, 2014·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Sara Darakhshan, Ali Bidmeshki Pour
May 28, 2016·Nature Reviews. Drug Discovery·Matthew D Breyer, Katalin Susztak
Oct 8, 1999·Plastic and Reconstructive Surgery·F B NiessenM Kon
Nov 28, 2018·Investigative Ophthalmology & Visual Science·Yoko Ogawa
Apr 14, 2010·Nature Reviews. Rheumatology·Manuel Ramos-CasalsAntoni Sisó-Almirall
May 3, 2019·Npj Regenerative Medicine·Ilja L Kruglikov, Philipp E Scherer
Jun 1, 1997·Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery·S ShigekiY Ikuta
Nov 13, 2009·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Seung Joon KimYoung Kyoon Kim
May 27, 2011·Clinical Pharmacology and Therapeutics·Y PouliotA J Butte
Sep 13, 2020·Pediatric Rheumatology Online Journal·Barbara JensenDespina Eleftheriou
Nov 6, 2020·Drug Design, Development and Therapy·Motoyasu KatoKazuhisa Takahashi
Apr 16, 2021·Journal of Wound Care·Parviz SorooshianFerdinand V Lali

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