Tranilast stabilizes the accumulation and degranulation of resident mast cells while reducing cardiomyocyte apoptosis in a swine model of coronary microembolisation

Clinical and Experimental Pharmacology & Physiology
Qing-Yong ZhangMeng Wei

Abstract

1. Coronary microembolisation (CME) is associated with progressive myocardial dysfunction, and mast cells (MC) might have an important role in myocardial apoptosis after CME. We investigated whether the MC stabilizer tranilast suppresses the accumulation and degranulation of MC while reducing cardiomyocyte apoptosis after CME. 2. We induced CME in miniswine by selective infusion of 15 x 10(4) microspheres (diameter 45 microm) into the left anterior descending artery. Some CME-induced miniswine were treated with the MC stabilizer tranilast (50 mg/kg, p.o., b.d.) beginning 2 weeks before CME, and thereafter throughout the experimental period; others received tranilast without CME; and sham-operated animals without CME served as controls. After 30 days, we assessed cardiomyocyte apoptosis by TUNEL assay and by the total number of MC and the number of degranulating MC using histology and transmission electron microscopy. The wall motion score index and left ventricular ejection fraction were studied by dobutamine stress echocardiography. 3. Coronary microembolisation was associated with increases in the total number of MC, the number of degranulating MC, and myocyte apoptosis. The number of total MC and degranulating MC and apoptot...Continue Reading

References

Jan 1, 1985·International Archives of Allergy and Applied Immunology·A KodaM Nakazawa
Sep 1, 1989·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·N B SchillerI Schnittger
Jul 18, 2000·Journal of the American College of Cardiology·R Erbel, G Heusch
Nov 22, 2000·American Journal of Physiology. Heart and Circulatory Physiology·H DörgeG Heusch
Sep 16, 2004·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Ahmet AkgulKeith A Youker
Dec 14, 2005·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Qing-Yong ZhangHung-Fat Tse
Oct 3, 2006·Journal of the American College of Cardiology·Jiyoong KimMasafumi Kitakaze
Feb 23, 2007·The New England Journal of Medicine·Paolo G Camici, Filippo Crea
Apr 10, 2007·The Journal of Surgical Research·Jama JahanyarGeorge P Noon
Jun 1, 2007·The New England Journal of Medicine·J Roberto Duran, George Taffet
Aug 28, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Darren J KellyRichard E Gilbert
Dec 15, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Hanna M HeikkiläKen A Lindstedt

❮ Previous
Next ❯

Citations

Oct 16, 2012·The International Journal of Cardiovascular Imaging·Maythem SaeedMark W Wilson
Oct 18, 2014·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Shaomin ChenWei Gao
Jan 22, 2013·Pharmacology & Therapeutics·Simon KennedyPasquale Maffia

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.