Dec 1, 1975

Tranquilizers or anti-depressants for chronic schizophrenics: a long term study

The Australian and New Zealand Journal of Psychiatry
J S TejaC Warren

Abstract

The relative efficacy of 4 tranquilizers was investigated in 66 chronic schizophrenics who had been hospitalized for 10.01 years (mean). The role of adding an anti-depressant was also studied. Following a 4 week placebo period, high dosage tranquilizers were given for 16 weeks and amitriptyline was added for the following 16 weeks. Statistical analyses of the various change measures revealed that patients worsened significantly on placebo, all 4 tranquilizers were significantly better than placebo for symptom reduction and maximum improvement was attained within 16 weeks of tranquilizer administration. No significant differences in efficacy were observed among the 4 tranquilizers and addition of amitriptyline did not confer any additional therapeutic advantage.

  • References15
  • Citations13

References

  • References15
  • Citations13

Citations

Mentioned in this Paper

Antipsychotic Effect
Schizophrenia
Polychemotherapy
Amitriptyline Hydrochloride
Clinical Trials
Placebos

About this Paper

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