Trans-chalcone added in topical formulation inhibits skin inflammation and oxidative stress in a model of ultraviolet B radiation skin damage in hairless mice

Journal of Photochemistry and Photobiology. B, Biology
Renata M MartinezRubia Casagrande

Abstract

Trans-chalcone (TC) is a common precursor of flavonoids. However, the pharmacological properties of TC remain to be fully understood. The present study investigated whether topical formulation containing TC (TFcTC) presents therapeutic effect in UVB radiation-induced skin damage using disease, enzyme activity, antioxidant activity, protein and mRNA parameters. Control topical formulation (CTF) and TFcTC were applied in hairless mice before and after exposure to UVB radiation. Dorsal skin samples were collected after UVB exposure to evaluate: i) skin edema (weight) was measured by punch biopsy; ii) spectrophotometric assays were used to measure myeloperoxidase (MPO) and catalase activities, ferric (FRAP) and ABTS cation reducing antioxidant power, superoxide anion production and levels of reduced glutathione (GSH); iii) enzymography was used to measure matrix metalloproteinase-9 (MMP-9) activity; iv) chemiluminescence was used to measure the lipid peroxidation (LPO); v) enzyme-linked immunosorbent assay (ELISA) was used to measure tumor necrosis factor alpha (TNF-α) levels; vi) reverse transcription quantitative PCR (RT-qPCR) was used to measure cyclooxygenase-2 (COX-2), gp91(phox) (NADPH oxidase sub-unity), glutathione peroxida...Continue Reading

Citations

Jul 25, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Matheus de Freitas SilvaAndrea Tarozzi
Dec 24, 2019·Nanomedicine·Agnieszka Małgorzata PudlarzJanusz Szemraj
Oct 20, 2018·Frontiers in Pharmacology·Larissa Staurengo-FerrariWaldiceu A Verri
Feb 14, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Camila R FerrazWaldiceu A Verri
Apr 10, 2019·European Journal of Pharmacology·Milena Menegazzo Miranda-SaplaWander Rogerio Pavanelli
Jul 24, 2021·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Cristina P B MeloRubia Casagrande
Aug 28, 2021·Biomolecules·Hiba A JasimSatyajit D Sarker

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