Trans-cinnamaldehyde improves neuroinflammation-mediated NMDA receptor dysfunction and memory deficits through blocking NF-κB pathway in presenilin1/2 conditional double knockout mice.

Brain, Behavior, and Immunity
Yang ZhaoYing Xu

Abstract

A chronic neuroinflammatory response has been considered as a critical pathogenesis promoting neurodegenerative progression in Alzheimer's disease (AD). During neuroinflammatory process, microglia are excessively activated and simultaneously release numerous pro-inflammatory mediators that cause synaptic dysfunction in the forebrain prior to neuronal degeneration and memory deficits in AD. Thus, prevention of neuroinflammation-mediated synaptic dysfunction may be a potential therapeutic approach against neurodegenerative disorders. Trans-cinnamaldehyde (TCA) is a primary bioactive component derived from the stem bark of Cinnamomum cassia, and it possesses potent anti-inflammatory and neuroprotective activities in in vivo and in vitro experiments. However, the in-depth molecular mechanisms of TCA underlying anti-neuroinflammatory and neuroprotective effects on memory deficits in AD are still unclear. The presenilin 1 and 2 conditional double knockout (PS cDKO) mice exhibit AD-like phenotypes including obvious neuroinflammatory responses and synaptic dysfunction and memory deficits. Here, PS cDKO were used to evaluate the potential neuroprotective effects of TCA against neuroinflammation-mediated dementia by performing behavioral...Continue Reading

References

May 1, 1991·Trends in Neurosciences·M GoedertC C Garner
Jan 1, 1994·Annual Review of Immunology·P A Baeuerle, T Henkel
Jan 7, 1993·Nature·T V Bliss, G L Collingridge
Jan 3, 2001·The Journal of Clinical Investigation·A S Baldwin
Jan 17, 2002·The New England Journal of Medicine·B A in t' VeldB H Stricker
Oct 26, 2002·Science·Dennis J Selkoe
May 19, 2004·Proceedings of the National Academy of Sciences of the United States of America·Ruiben FengJoe Z Tsien
Aug 3, 2004·Journal of Neuroinflammation·Susanna RosiGary L Wenk
Sep 4, 2004·The Journal of Biological Chemistry·Vassilios BeglopoulosJie Shen
Jan 13, 2006·British Journal of Pharmacology·Jeffrey C Watkins, David E Jane
Aug 26, 2006·Science·Jonathan R WhitlockMark F Bear
May 9, 2007·Biogerontology·Dae Hyun KimHae Young Chung
Jan 15, 2008·Journal of Neuroscience Research·Qian ChenYa-Ping Tang
Jan 16, 2008·Journal of Cellular and Molecular Medicine·K Iqbal, I Grundke-Iqbal
Dec 17, 2008·Seminars in Cell & Developmental Biology·Matthew R HassGuojun Zhao
Jan 24, 2009·Trends in Neurosciences·Tara L Spires-JonesBradley T Hyman
May 15, 2010·Mediators of Inflammation·Byung Hun KimJae Youl Cho
Jun 29, 2010·Acta Pharmacologica Sinica·Jia-hua ZhangShi-ang Huang
Nov 26, 2010·Proceedings of the National Academy of Sciences of the United States of America·Yong-Jun ChenTian-Ming Gao
Mar 5, 2011·Lancet·Clive BallardEmma Jones
Apr 19, 2011·Mass Spectrometry Reviews·Giuseppe Grasso
Jan 9, 2013·Neurobiology of Disease·Massimiliano Di FilippoPaolo Calabresi
Mar 21, 2015·Lancet Neurology·Michael T HenekaMarkus P Kummer
May 21, 2015·Nature Reviews. Neuroscience·Frank L HeppnerBurkhard Becher
Oct 8, 2015·Trends in Neurosciences·Siddhita D MhatreKatrin I Andreasson
Jul 9, 2016·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Akshay JawaleShyam S Sharma

❮ Previous
Next ❯

Citations

Apr 19, 2020·Brain, Behavior, and Immunity·Keith W KelleyAtsuyoshi Shimada
Oct 30, 2020·Neuropsychiatric Disease and Treatment·Jing Wang, Xingmao Wu
Dec 5, 2020·BioMed Research International·Mehrdad HajinejadSajad Sahab-Negah
Nov 14, 2020·Neurochemistry International·Ahilya SinghGerald Münch

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: Microglia

Microglia are a type of glial cell found throughout the brain and spinal cord. Microglia have been found to be associated with Alzheimer's disease development and progression. Here are the latest discoveries pertaining to Alzheimer's disease and microglia.