Trans-cinnamic aldehyde inhibits Aggregatibacter actinomycetemcomitans-induced inflammation in THP-1-derived macrophages via autophagy activation.

Journal of Periodontology
Jin ChungHee Sam Na

Abstract

Inflammation is an essential response against bacterial infection as a host defense mechanism, which can lead to tissue damage. Aggregatibacter actinomycetemcomitans (Aa) is major pathogen for aggressive periodontitis characterized by rapid destruction of periodontal tissue surrounding teeth. Trans-cinnamic aldehyde is a key bioactive compound of the cinnamon extracts, which has anti-inflammatory, antioxidant, antipyretic, antimicrobial, and anti-cancer properties. The objective of the present study was to investigate the anti-inflammatory effect of trans-cinnamic aldehyde against Aa infection in human THP-1 derived macrophages and on Aa-induced periodontitis in mice. THP-1 cells were differentiated with phorbol 12-mystristate 13-acetate and were infected with live Aa. Trans-cinnamic aldehyde was pretreated 30 minutes before the bacterial infection. Cytokine production was determined by enzyme-linked immunosorbent assay (ELISA) and protein expressions were detected by Western blot analysis. Autophagosome formation was detected by Cyto-ID. Viable cell count was carried out to determine bacterial adhesion, internalization, and intracellular survival. Experimental periodontitis was induced by inoculating Aa orally to mice, and mic...Continue Reading

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Citations

Jan 24, 2019·Oral Diseases·Ming JiangGuangxun Zhu
Nov 29, 2020·Journal of Periodontal Research·Yuhui YangWeiran Li
Dec 8, 2020·Biochimica Et Biophysica Acta. Molecular Cell Research·Li MaZhengguo Cao
Apr 12, 2019·Archives of Oral Biology·Alejandro I Lorenzo-PousoYago Leira
Dec 7, 2021·Frontiers in Immunology·Bo YangYan Wang

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