Trans-differentiation of neural stem cells: a therapeutic mechanism against the radiation induced brain damage.

PloS One
Kyeung Min JooDo-Hyun Nam

Abstract

Radiation therapy is an indispensable therapeutic modality for various brain diseases. Though endogenous neural stem cells (NSCs) would provide regenerative potential, many patients nevertheless suffer from radiation-induced brain damage. Accordingly, we tested beneficial effects of exogenous NSC supplementation using in vivo mouse models that received whole brain irradiation. Systemic supplementation of primarily cultured mouse fetal NSCs inhibited radiation-induced brain atrophy and thereby preserved brain functions such as short-term memory. Transplanted NSCs migrated to the irradiated brain and differentiated into neurons, astrocytes, or oligodendrocytes. In addition, neurotrophic factors such as NGF were significantly increased in the brain by NSCs, indicating that both paracrine and replacement effects could be the therapeutic mechanisms of NSCs. Interestingly, NSCs also differentiated into brain endothelial cells, which was accompanied by the restoration the cerebral blood flow that was reduced from the irradiation. Inhibition of the VEGF signaling reduced the migration and trans-differentiation of NSCs. Therefore, trans-differentiation of NSCs into brain endothelial cells by the VEGF signaling and the consequential rest...Continue Reading

References

Apr 4, 1997·Science·R McKay
Nov 10, 1998·Journal of Neurology·F Keime-GuibertJ Y Delattre
Feb 26, 2000·Science·F H Gage
Sep 7, 2000·The Journal of Comparative Neurology·T D PalmerF H Gage
Sep 12, 2001·Neurology·J M Wardlaw
Jun 29, 2002·Cellular Immunology·B C SchaeferR M Kedl
Jan 15, 2003·Current Treatment Options in Oncology·Sadaf Taimur, Martin J Edelman
Mar 26, 2003·International Journal of Radiation Oncology, Biology, Physics·Brian Patrick O'NeillJudith R O'Fallon
Jul 26, 2003·Stroke; a Journal of Cerebral Circulation·Christian DohmenWolf-Dieter Heiss
Nov 15, 2003·Science·Michelle L MonjeTheo D Palmer
Feb 5, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Fortunato CiardielloGiampaolo Tortora
Jul 29, 2004·Proceedings of the National Academy of Sciences of the United States of America·S KellyG K Steinberg
Jan 22, 2005·Annual Review of Medicine·Aarif Y Khakoo, Toren Finkel
Sep 2, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Corey J Langer, Minesh P Mehta
Sep 30, 2005·Behavioural Brain Research·Douglas WahlstenJohn C Crabbe
Dec 16, 2005·The New England Journal of Medicine·Dae Hyun Kim
Feb 24, 2006·Nature Reviews. Neuroscience·Pierre-Marie LledoMatthew S Grubb
Jun 9, 2006·Nature Reviews. Neuroscience·Gianvito Martino, Stefano Pluchino
Oct 13, 2006·Current Treatment Options in Oncology·Jerome M ButlerEdward G Shaw
Dec 18, 2007·Neurosurgical Focus·Jesse JonesMaryanne H Marymont
Jan 22, 2008·Biochemistry. Biokhimii︠a︡·O I StepanovaE P Kisseleva
Oct 8, 2008·Annals of the New York Academy of Sciences·Shaker AbdullahEric Bouffet
Mar 21, 2009·Journal of Neuroscience Research·Seung U Kim, Jean de Vellis
Aug 17, 2010·Southern Medical Journal·Elizabeth H DonnellySyed F Naeem
Nov 26, 2010·Nature·Rong WangViviane Tabar
Jan 25, 2013·Proceedings of the National Academy of Sciences of the United States of America·Yuchang LiKinji Asahina
May 15, 2015·Radiation Protection Dosimetry·I PecchiaM A Tabocchini

❮ Previous
Next ❯

Citations

Jul 17, 2014·Clinical Oncology : a Journal of the Royal College of Radiologists·L C WelshK L Newbold
Feb 8, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Dana Greene-SchloesserMike E Robbins
Feb 28, 2016·Stem Cell Research·Vivian Capilla-GonzalezAlfredo Quiñones-Hinojosa
Nov 28, 2015·International Journal of Molecular Sciences·Sona Balentova, Marian Adamkov
Sep 22, 2012·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Ákos FábiánJános Szöllősi
Nov 26, 2015·Environmental and Molecular Mutagenesis·Janet E BaulchCharles L Limoli
Oct 30, 2013·International Journal of Radiation Biology·Antiño R AllenJohn R Fike
Oct 31, 2013·International Journal of Radiation Biology·Paola Ballesteros-ZebaduaCarlos Paz
Jan 5, 2014·PloS One·Samuel McLenachanFred K Chen
Feb 10, 2018·Current Stem Cell Reports·Sarah M Smith, Charles L Limoli
Nov 16, 2016·Molecular Neurobiology·Mohammad Hossein GeranmayehMehdi Farhoudi
Jun 4, 2019·Frontiers in Cellular Neuroscience·Bernat SoriaVivian Capilla-González
Aug 28, 2019·Genes·Anna MichaelidesováMartina Zíková
May 18, 2020·Stem Cell Reviews and Reports·Chengyan ChuShen Li
Aug 29, 2020·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·C ChargariJ-M Simon
Apr 28, 2021·Journal of Environmental Science and Health. Part C, Toxicology and Carcinogenesis·Catherine M DavisDawn E Bowles

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic
PCR
flow cytometry
imaging technique
FACS
ELISA

Software Mentioned

ImageScope

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Astrocytes & Neurodegeneration

Astrocytes are important for the health and function of the central nervous system. When these cells stop functioning properly, either through gain of function or loss of homeostatic controls, neurodegenerative diseases can occur. Here is the latest research on astrocytes and neurodegeneration.

Cancer Stem Cells in Glioblastoma

Glioblastoma is the most common and aggressive type of brain tumor. It contains a population of tumor initiating stem cell-like cells known as cancer stem cells. Investigations are ongoing into these cancer stem cells found in these solid tumors which are highly resistance to treatment. Here is the latest research on cancer stem cells in glioblastoma.

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Related Papers

The New England Journal of Medicine
Zurab Nadareishvili, John Hallenbeck
The New England Journal of Medicine
Sunit Das, Philip A Marsden
© 2022 Meta ULC. All rights reserved