PMID: 11331618May 2, 2001Paper

Trans-ethnic fine mapping of a quantitative trait locus for circulating angiotensin I-converting enzyme (ACE)

Human Molecular Genetics
Colin A McKenzieLon R Cardon

Abstract

Circulating angiotensin I-converting enzyme (ACE) levels are influenced by a major quantitative trait locus (QTL) that maps to the ACE gene. Phylogenetic and measured haplotype analyses have suggested that the ACE-linked QTL lies downstream of a putative ancestral breakpoint located near to position 6435. However, strong linkage disequilibrium between markers in the 3' portion of the gene has prevented further resolution of the QTL in Caucasian subjects. We have examined 10 ACE gene polymorphisms in Afro-Caribbean families recruited in JAMAICA: Variance components analyses showed strong evidence of linkage and association to circulating ACE levels. When the linkage results were contrasted with those from a set of British Caucasian families, there was no evidence for heterogeneity between the samples. However, patterns of allelic association between the markers and circulating ACE levels differed significantly in the two data sets. In the British families, three markers [G2215A, Alu insertion/deletion and G2350A] were in complete disequilibrium with the ACE-linked QTL. In the Jamaican families, only marker G2350A showed strong but incomplete disequilibrium with the ACE-linked QTL. These results suggest that additional unobserved...Continue Reading

Citations

Jan 28, 2003·Trends in Genetics : TIG·Alan WrightHarry Campbell
Sep 7, 2012·Genetics Research·Kathryn E KemperMichael E Goddard
Jul 23, 2004·Nature·Michael MorleyVivian G Cheung
Jan 15, 2008·Nature Genetics·Serena SannaKaren L Mohlke
Jan 20, 2010·Nature Reviews. Genetics·Yik-Ying TeoDominic P Kwiatkowski
Mar 16, 2012·Current Opinion in Lipidology·Cristen J Willer, Karen L Mohlke
Aug 30, 2005·Annual Review of Genomics and Human Genetics·Dana C CrawfordDeborah A Nickerson
Apr 20, 2005·Human Heredity·Gonçalo R AbecasisThomas E Nichols
Mar 3, 2009·American Journal of Respiratory Cell and Molecular Biology·Paula TejeraDavid C Christiani
May 10, 2007·The Review of Diabetic Studies : RDS·Rachel M FreathyKenneth M Macleod
Oct 4, 2012·Trends in Immunology·Chris Cotsapas, David A Hafler
Apr 10, 2007·Seminars in Nephrology·Sudha K Iyengar, Sharon G Adler
Jun 15, 2005·Clinical and Experimental Dermatology·M AmeenJ N W N Barker
Aug 14, 2013·Annals of Human Genetics·Chikashi TeraoUNKNOWN Nagahama Cohort Research Group
Jun 17, 2014·Biochimica Et Biophysica Acta·Sumeet A Khetarpal, Daniel J Rader
Aug 12, 2006·Respiratory Medicine·Adrian KruitHenk J T Ruven
Aug 15, 2002·International Journal of Epidemiology·Bernard Keavney
Apr 13, 2004·Journal of Hypertension·Tatiana KuznetsovaUNKNOWN European Project On Genes in Hypertension (EPOGH) Investigators
Mar 2, 2011·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Yuan-Han QinYan-Jun Zhao
Jun 14, 2003·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Patrick G Kehoe
Sep 25, 2003·Journal of Human Hypertension·M Saeed MahmoodP M Frossard

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.