Trans fatty acid intake is associated with insulin sensitivity but independently of inflammation.

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas
C T AngelieriS R G Ferreira

Abstract

High saturated and trans fatty acid intake, the typical dietary pattern of Western populations, favors a proinflammatory status that contributes to generating insulin resistance (IR). We examined whether the consumption of these fatty acids was associated with IR and inflammatory markers. In this cross-sectional study, 127 non-diabetic individuals were allocated to a group without IR and 56 to another with IR, defined as homeostasis model assessment-IR (HOMA-IR) >2.71. Diet was assessed using 24-h food recalls. Multiple linear regression was employed to test independent associations with HOMA-IR. The IR group presented worse anthropometric, biochemical and inflammatory profiles. Energy intake was correlated with abdominal circumference and inversely with adiponectin concentrations (r = -0.227, P = 0.002), while saturated fat intake correlated with inflammatory markers and trans fat with HOMA-IR (r = 0.160, P = 0.030). Abdominal circumference was associated with HOMA-IR (r = 0.430, P < 0.001). In multiple analysis, HOMA-IR remained associated with trans fat intake (β = 1.416, P = 0.039) and body mass index (β = 0.390, P < 0.001), and was also inversely associated with adiponectin (β = -1.637, P = 0.004). Inclusion of other nutri...Continue Reading

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Citations

Mar 20, 2013·Mediators of Inflammation·Débora EstadellaAline de Piano
Apr 13, 2018·The British Journal of Nutrition·Carla de Magalhães CunhaAna Marlúcia Oliveira
Jan 4, 2013·Current Opinion in Gastroenterology·Emily R PeritoRobert H Lustig
Apr 29, 2020·Lipids in Health and Disease·Liying JiangAidong Liu
Jan 22, 2021·Public Health Nutrition·Adélia Cp Arruda NetaDirce M Marchioni

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay

Software Mentioned

Nutrition Data System
SPSS

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