PMID: 12761047May 23, 2003Paper

Trans mobilization of genomic DNA as a mechanism for retrotransposon-mediated exon shuffling

Human Molecular Genetics
Yosuke Ejima, Lichun Yang

Abstract

Exon shuffling, the juxtaposition and new combinations of exons from different genes, facilitates evolutionary changes by increasing protein diversity or by generating new function. Exon shuffling is generated as a consequence of segmental duplications. Long interspersed element (LINE)-1 (L1)-mediated 3' transduction is a potential pathway for exon shuffling by which L1 associates 3' flanking DNA in cis as a read-through transcript and carries the DNA to a new genomic location. In this pathway, however, the targets are limited to the regions located 3' to L1s. Here we propose that the genomic DNA distant from L1 may be mobilized by an alternative (trans) action of L1. A partial ATM sequence containing a single exon and flanking introns has been retrotransposed to a new genomic location on chromosome 7. There was no L1 around the exon of the authentic ATM locus. An unusual feature that the poly(A) tail tagged to the transposed sequence oriented oppositely to the ATM's transcriptional orientation suggests that a trans action of reverse transcriptase on antisense transcript has driven the duplication of genomic DNA without removing introns. Taking account of similar duplication events in previous studies, a certain class of segmen...Continue Reading

Citations

Jan 1, 2004·Journal of Biological Physics·Zhen QiRunsheng Chen
May 27, 2010·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Ivan MolinerisMichele Caselle
Mar 18, 2009·Molecular Biology and Evolution·Kenji K Kojima, Norihiro Okada
Dec 14, 2005·Genome Research·Leonard Lipovich, Mary-Claire King
Aug 12, 2005·Cytogenetic and Genome Research·J Brosius
Mar 17, 2010·Mobile DNA·James A Shapiro
Nov 19, 2003·PLoS Biology·Lincoln D SteinRobert H Waterston
Dec 14, 2007·Annual Review of Genetics·Cédric Feschotte, Ellen J Pritham
Apr 2, 2008·Chaos·Sergei LarionovEugeny Ryadchenko
Nov 15, 2006·Proceedings of the National Academy of Sciences of the United States of America·Jinchuan XingMark A Batzer
Mar 3, 2005·Proceedings of the National Academy of Sciences of the United States of America·Yi Zhou, Bud Mishra
Aug 2, 2011·Annual Review of Genomics and Human Genetics·Christine R BeckJohn V Moran
Jan 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·Claudia M B CarvalhoJames R Lupski
Nov 26, 2003·Current Opinion in Genetics & Development·Prescott L DeiningerHaig H Kazazian
Jun 3, 2014·The Journal of Physiology·James A Shapiro
Apr 20, 2007·Gene·Wanjun GuDavid D Pollock
Dec 13, 2006·Mutation Research·David A RayMark A Batzer
Jun 19, 2008·Animal Genetics·S E HizerD K Garcia
Nov 19, 2011·Human Mutation·Szilvia SolyomHaig H Kazazian
Nov 12, 2003·American Journal of Human Genetics·Sheila M LutzJohn V Moran
Feb 28, 2014·RNA Biology·James A Shapiro
Mar 13, 2012·Current Opinion in Genetics & Development·Dustin C Hancks, Haig H Kazazian
Sep 10, 2010·Journal of Human Genetics·Hiroyuki AwanoMasafumi Matsuo
Nov 30, 2007·American Journal of Physical Anthropology·Jinchuan XingLynn B Jorde
May 27, 2021·Fish & Shellfish Immunology·Alessia AmetranoMaria Rosaria Coscia

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