Trans-oral anterior fundoplication: 5-year follow-up of pilot study

Surgical Endoscopy
Aviel Roy-ShapiraShivangi Dorwat

Abstract

This is a report of an IRB-approved pilot study of 13 patients who received a trans-oral anterior partial fundoplication for the treatment of GERD using an ultrasound-guided, flexible surgical stapler. All patients had a history of PPI use, objective evidence of GERD, and no significant comorbidity. Under general anesthesia, a flexible stapler was passed trans-orally into the stomach and placed two or three quintuplets of titanium staples approximately 3 cm above the gastroesophageal junction. The stapler contains an ultrasonic range finder, video camera, and illuminator. Primary follow-up at 6 weeks included pH metrics, GERD-HRQL scores, and PPI use. The protocol allowed annual telephone interviews for the following 5 years to collect GERD-HRQL scores, PPI use, satisfaction with the procedure, and willingness to have the procedure again. At 6 weeks, mean total acid exposure was significantly reduced, and 12/13 patients reduced GERD-HRQL scores by ≥50 %. Twelve of 13 patients had stopped daily GERD medications, and nine of 13 had stopped all GERD medications. Each year, 11 of the 13 patients could be reached with all 13 patients having at least 4-year follow-up. Throughout the follow-up period, GERD-HRQL scores were normal (<10...Continue Reading

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References

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Citations

May 10, 2016·World Journal of Gastrointestinal Pharmacology and Therapeutics·Pier Alberto TestoniSabrina Gloria Giulia Testoni
Jan 18, 2018·Current Treatment Options in Gastroenterology·Carol RouphaelPrashanthi N Thota
Feb 10, 2017·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·K U AscheR Pointner
May 27, 2021·Endoscopy·Pier Alberto TestoniSandro Passaretti

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