Trans-scleral iontophoretic delivery of low molecular weight therapeutics

Journal of Controlled Release : Official Journal of the Controlled Release Society
Sevgi GüngörRichard H Guy

Abstract

The fundamental understanding of ocular drug delivery using iontophoresis is not at the same level as that for transdermal electrotransport. Research has therefore been undertaken to characterise the electrical properties of the sclera (charge, permselectivity, and isoelectric point (pI)) and to determine the basics of iontophoretic transport of model neutral, cationic, and anionic species (respectively, mannitol, timolol, and dexamethasone phosphate). Like the skin, the sclera supports a net negative charge under physiological pH conditions and has a pI between 3.5 and 4. Equally, the principles of trans-scleral iontophoretic transport of low molecular weight compounds are consistent with those observed for skin. Iontophoretic delivery of timolol and dexamethasone phosphate was proportional to applied current and drug concentration, and trans-scleral iontophoresis in rabbits led to enhanced intraocular levels of these compounds compared to passive delivery. The behaviour of higher molecular weight species such as peptide drugs and other biopharmaceuticals (e.g., proteins and oligonucleotides) has not been fully characterised. Further work has been undertaken, therefore, to examine the trans-scleral iontophoresis of vancomycin,...Continue Reading

References

Sep 1, 1989·Archives of Ophthalmology·T T LamM O Tso
Oct 1, 1974·Archives of Ophthalmology·T KrupinB Becker
Jun 30, 2000·Clinical and Experimental Pharmacology & Physiology·N M Davies
Feb 13, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·D MarroM B Delgado-Charro
Jun 19, 2004·Journal of Drug Targeting·Dimitrios G Fatouros, Joke A Bouwstra
Oct 20, 2004·Retina·Rama D JagerEmmett T Cunningham
Mar 1, 2005·Journal of Pharmaceutical Sciences·S Kevin LiHenry S White
Jul 20, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Esther Eljarrat-BinstockAbraham J Domb
Sep 10, 2005·Optometry : Journal of the American Optometric Association·Michelle L Reichle
Dec 14, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Esther Eljarrat-Binstock, Abraham J Domb
Mar 2, 2006·Expert Opinion on Drug Delivery·Deepta Ghate, Henry F Edelhauser
Jul 30, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·J-P SylvestreR H Guy
Aug 23, 2008·Physical Therapy·Jean-Philippe SylvestreM Begoña Delgado-Charro
Dec 27, 2008·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Sara NicoliPatrizia Santi

❮ Previous
Next ❯

Citations

Jul 13, 2013·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Michael A PataneBegona Ruiz-Perez
Jan 7, 2014·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Hidemasa KatsumiAkira Yamamoto
Jul 25, 2012·Therapeutic Delivery·Silvia PescinaSara Nicoli
Jun 6, 2014·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Jian-Hai BaiHao Cui
May 13, 2014·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·E TrattaS Nicoli
Mar 17, 2015·Translational Vision Science & Technology·Juan-Carlos Gutiérrez-HernándezMark Humayun
Dec 14, 2011·Expert Opinion on Drug Delivery·Maria Begoña Delgado-Charro
Apr 30, 2013·Expert Opinion on Emerging Drugs·Neha Gadaria-RathodPenny A Asbell
Sep 2, 2015·Drug Development and Industrial Pharmacy·Linda DuxfieldRaida Al-Kassas
Nov 28, 2013·Expert Opinion on Emerging Drugs·Theresa G Leung, Jennifer E Thorne
May 15, 2013·Journal of Pharmaceutical Sciences·Lasse MurtomäkiSara Nicoli
Jan 3, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Joel G SouzaRenata F V Lopez
Feb 7, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Poonam ChopraS Kevin Li
Mar 1, 2011·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Silvia PescinaSara Nicoli
Aug 21, 2015·Ophthalmology and Therapy·Laura A Vickers, Preeya K Gupta
Mar 15, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Silvia PescinaLasse Murtomäki
Nov 29, 2016·Expert Opinion on Drug Delivery·Taís GratieriYogeshvar N Kalia
Feb 13, 2018·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Kongnara PapangkornWilliam I Higuchi
Sep 3, 2017·British Journal of Pharmacology·Sahar AwwadAlastair Lockwood
Nov 23, 2019·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Victor L PerezMichael Raizman
Nov 18, 2017·Expert Opinion on Drug Delivery·S Kevin Li, Jinsong Hao
Oct 28, 2018·Pharmaceutics·Tomasz M Karpiński
Oct 24, 2017·Veterinary Sciences·Panditharathnalage Nishantha Kumara WijesekaraDiwan Rawat
Apr 7, 2019·Drug Discovery Today·Jae Hwan JungMark R Prausnitz
Mar 7, 2021·Biomolecules·Dylan E ParsonsVinit B Mahajan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
Sara NicoliPatrizia Santi
Journal of Controlled Release : Official Journal of the Controlled Release Society
Esther Eljarrat-Binstock, Abraham J Domb
International Journal of Pharmaceutics
Poonam ChopraS Kevin Li
© 2021 Meta ULC. All rights reserved