Trans-species polymorphism in humans and the great apes is generally maintained by balancing selection that modulates the host immune response

Human Genomics
Luisa AzevedoDavid N Cooper

Abstract

Known examples of ancient identical-by-descent genetic variants being shared between evolutionarily related species, known as trans-species polymorphisms (TSPs), result from counterbalancing selective forces acting on target genes to confer resistance against infectious agents. To date, putative TSPs between humans and other primate species have been identified for the highly polymorphic major histocompatibility complex (MHC), the histo-blood ABO group, two antiviral genes (ZC3HAV1 and TRIM5), an autoimmunity-related gene LAD1 and several non-coding genomic segments with a putative regulatory role. Although the number of well-characterized TSPs under long-term balancing selection is still very small, these examples are connected by a common thread, namely that they involve genes with key roles in the immune system and, in heterozygosity, appear to confer genetic resistance to pathogens. Here, we review known cases of shared polymorphism that appear to be under long-term balancing selection in humans and the great apes. Although the specific selective agent(s) responsible are still unknown, these TSPs may nevertheless be seen as constituting important adaptive events that have occurred during the evolution of the primate immune ...Continue Reading

References

May 17, 1990·Nature·F YamamotoS Hakomori
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·U B Gyllensten, H A Erlich
Sep 15, 1988·Nature·F FigueroaJ Klein
Jan 1, 1993·Immunogenetics·J M MartinkoJ Klein
Dec 11, 1999·Nucleic Acids Research·E M SmigielskiS T Sherry
Jul 24, 2002·Immunogenetics·Nel OttingRonald E Bontrop
Aug 15, 2002·Proceedings of the National Academy of Sciences of the United States of America·Dustin J PennWayne K Potts
Sep 21, 2002·Immunogenetics·Yasuhiro GoHirohisa Hirai
Jan 15, 2004·Immunogenetics·José A M BorghansRob J De Boer
Oct 22, 2004·Nature Immunology·Paul D Bieniasz
Feb 1, 2005·Trends in Genetics : TIG·Saurabh AsthanaShamil Sunyaev
Feb 4, 2005·Proceedings of the National Academy of Sciences of the United States of America·Sara L SawyerHarmit S Malik
Oct 22, 2005·Infection and Immunity·Jason B HarrisStephen B Calderwood
Jul 4, 2006·Molecular Phylogenetics and Evolution·Michael E Steiper, Nathan M Young
Oct 21, 2006·Proceedings of the National Academy of Sciences of the United States of America·Dagan A LoiselSusan C Alberts
Dec 5, 2006·Proceedings of the National Academy of Sciences of the United States of America·Ruchi M NewmanWelkin E Johnson
Jun 26, 2007·Science·Shari M KaiserMichael Emerman
Dec 14, 2007·Journal of Virology·Valérie GoldschmidtAmalio Telenti
Sep 27, 2008·Genome Biology·Rachele CaglianiManuela Sironi
Dec 17, 2008·Clinical and Experimental Immunology·A M Ercolini, S D Miller
Aug 29, 2009·Molecular Biology and Evolution·Aida M AndrésRasmus Nielsen
Jan 15, 2010·Proceedings. Biological Sciences·Lewis G Spurgin, David S Richardson
Mar 24, 2010·Blood·David J Anstee
Dec 7, 2011·Proceedings of the National Academy of Sciences of the United States of America·Diamantis SellisPhilipp W Messer
Mar 9, 2012·Nature·Aylwyn ScallyRichard Durbin
Jun 15, 2012·Journal of Virology·P JáureguiR Reina
Aug 15, 2012·Proceedings of the National Academy of Sciences of the United States of America·Kevin E LangergraberLinda Vigilant
Oct 4, 2012·BMC Evolutionary Biology·Katarzyna KudukJacek Radwan
Oct 24, 2012·Proceedings of the National Academy of Sciences of the United States of America·Laure SégurelMolly Przeworski
Jan 16, 2013·International Journal of Cancer. Journal International Du Cancer·Cosmeri RizzatoFederico Canzian

❮ Previous
Next ❯

Citations

Oct 16, 2009·PloS One·Marianne L SeneyNancy G Forger
Feb 9, 2017·Molecular Ecology·Violaine LlaurensMathieu Joron
Jan 4, 2017·Biochemistry Research International·Eliane EvanovichMaria Lúcia Harada
Aug 16, 2017·Nature Ecology & Evolution·Rosalyn GloagBenjamin P Oldroyd
Nov 5, 2017·Nature Communications·Jackie LightenCock van Oosterhout
Aug 30, 2020·Nature Reviews. Genetics·Dieter Ebert, Peter D Fields
Oct 6, 2016·Genome Biology and Evolution·Anna FijarczykWieslaw Babik
Apr 17, 2018·Genetics and Molecular Biology·Lucas Henriques ViscardiMaria Cátira Bortolini
Mar 28, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mark S GibsonJohn A Hammond
Jan 18, 2018·PeerJ·Michael W HartIngemar Kaj
May 19, 2018·Scientific Reports·Mary Regina BolandAnna R Gelzer
Nov 25, 2019·Human Genetics·Jacques Le Pendu, Nathalie Ruvoën-Clouet
Jan 8, 2021·Nature Reviews. Genetics·Mary Lauren BentonJohn A Capra
Jun 18, 2017·Journal of Human Evolution·Alexis P SullivanGeorge H Perry
Mar 28, 2021·Proceedings of the National Academy of Sciences of the United States of America·Ronnie M RussellBeatrice H Hahn
Apr 22, 2021·Proceedings of the National Academy of Sciences of the United States of America·Molly Ohainle, Harmit S Malik

❮ Previous
Next ❯

Methods Mentioned

BETA
deamination

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.