PMID: 8613141Jan 1, 1996Paper

Trans-species polymorphism of class II Mhc loci in danio fishes

Immunogenetics
R GraserJ Klein

Abstract

A characteristic feature of the major histocompatibility complex (Mhc) polymorphism in mammals is the existence of allelic lineages shared by related species. This trans-species polymorphism has thus far been documented only in primates, rodents, and artiodactyls. In this communication we provide evidence that it also exists in cyprinid (bony) fishes at the class II A and B loci coding for the alpha and beta polypeptide chains of the class II alpha:beta heterodimers. The study has focused on three species of the family Cyprinidae, subfamily Rasborinae: the zebrafish (Danio rerio), the giant danio (D. malabaricus), and the pearl danio (D. albolineatus). The polymerase chain reaction was used to amplify and then sequence intron 1 and exon 2 of the class II B loci and exon 2 of the class II A loci in these species. Phylogenetic analysis of the sequences revealed the existence of allelic lineages whose divergence predates the divergence of the three species at both the A and B loci. The lineages at the B locus in particular are separated by large genetic distances. The polymorphism is concentrated in the peptide-binding region sites and is apparently maintained by balancing selection. Sharing of this unique Mhc feature by both bony...Continue Reading

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Feb 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·S M Stanley
Jan 1, 1992·Immunogenetics·M KenterR E Bontrop
Jan 1, 1992·Immunogenetics·W E MayerJ Klein
Dec 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·H OnoJ Klein
Apr 1, 1992·Computer Applications in the Biosciences : CABIOS·D G HigginsR Fuchs
Aug 11, 1991·Nucleic Acids Research·P W LairdA Berns
Feb 1, 1990·Immunological Reviews·J Klein, N Takahata
Feb 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·A L Hughes, M Nei
Oct 1, 1989·Human Immunology·W M FanJ Klein
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·U B Gyllensten, H A Erlich
Apr 14, 1988·Nature·T J McConnellE K Wakeland
Sep 15, 1988·Nature·F FigueroaJ Klein
Jan 1, 1984·Bulletin of Mathematical Biology·S J Nelson
Apr 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·B Arden, J Klein
Feb 1, 1995·Immunological Reviews·C O'hUigin
Feb 1, 1995·Immunological Reviews·J Klein, C O'hUigin
Jul 1, 1994·Developmental and Comparative Immunology·R B WalkerR A Walker
Aug 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·Y SattaJ Klein
Jan 1, 1993·Annual Review of Immunology·J KleinN Takahata
Jan 1, 1993·Immunogenetics·H OnoJ Klein

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Citations

Jun 27, 2007·Journal of Molecular Evolution·Andres Aguilar, John Carlos Garza
Jan 1, 1997·Developmental and Comparative Immunology·U B GodwinT J McConnell
Apr 29, 1999·Developmental and Comparative Immunology·S S RistowG H Thorgaard
Dec 30, 1999·Veterinary Immunology and Immunopathology·T NakanishiM Ototake
Aug 1, 1998·Trends in Ecology & Evolution·S V Edwards, P W Hedrick
Aug 30, 2008·Fish & Shellfish Immunology·Elisa RandelliGiuseppe Scapigliati
Nov 19, 2011·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Pascal J LafontantTyler D Frounfelter
Nov 3, 2004·Fish & Shellfish Immunology·Eva OttováSerge Morand
Sep 1, 2014·Current Opinion in Genetics & Development·Felix M KeyAida M Andrés
Dec 18, 2014·Immunogenetics·Catalina Gonzalez-QuevedoDavid S Richardson
Jul 28, 2005·Developmental and Comparative Immunology·Song-Lin ChenCheng-Fang Dong
Jul 25, 2018·Journal of Developmental Biology·Olubusola ShifatuPascal J Lafontant

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