trans-Stilbene oxide: an inducer of rat hepatic microsomal and nuclear epoxide hydrase and mixed-function oxidase activities

Chemico-biological Interactions
H MukhtarJ R Bend

Abstract

The administration of trans-stilbene oxide to rats resulted in increased hepatic microsomal and nuclear epoxide hydrase (with styrene oxide (SO), benzo[a]pyrene 4,5-oxide (4,5-BP) as substrates) and aryl hydrocarbon hydroxylase (AHH) activities. Hepatic microsomal aminopyrine N-demethylase, benzphetamine N-demethylase, and ethylmorphine N-demethylase activities were also increased. These increases in microsomal enzyme activity were dose- and time-dependent (about 100% at 200 mg/kg body weight, administered for 2 consecutive days). However, only marginal increases in hepatic microsomal NADPH-cytochrome c reductase activity and cytochrome P-450 content were observed. No apparent proliferation of hepatic endoplasmic reticulum occurred in trans-stilbene oxide pretreated rats. The administration of trans-stilbene oxide has no effect on hepatic glutathione S-transferase activities (with SO or 4,5-BPO as substrates). None of the parameters were affected in pulmonary microsomes from treated rats. The in vitro addition of trans-stilbene oxide (10(-6)--10(-2) M) did not affect hepatic epoxide hydrase or glutathione S-transferase activities.

References

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Citations

Sep 1, 1980·Chemico-biological Interactions·E GarattiniM Salmona
Jan 1, 1981·Progress in Biophysics and Molecular Biology·P J Quinn
Dec 29, 1983·Biochimica Et Biophysica Acta·J Seidegård, J W DePierre
Jan 1, 1983·Drug Metabolism Reviews·M RomanoM Salmona
Jun 30, 1979·Toxicology and Applied Pharmacology·B R Smith, J R Bend
Dec 1, 1982·Toxicology and Applied Pharmacology·T N ThompsonC D Klaassen
Jan 1, 1979·Biochemical Pharmacology·T H Elmamlouk, H Mukhtar
Dec 15, 1987·Biochemical Pharmacology·P RauchL W Robertson
Feb 1, 1980·Environmental Health Perspectives·J J Lech, J R Bend
Feb 1, 1980·Chemico-biological Interactions·G GazzottiM Salmona
Apr 1, 1985·Biochemical Pharmacology·S P SrivastavaH Mukhtar
Aug 1, 1980·Biochimica Et Biophysica Acta·C GuthenbergB Mannervik
Jan 1, 1979·Archives of Biochemistry and Biophysics·H MukhtarJ R Bend
Feb 11, 1982·Biochemical and Biophysical Research Communications·R DixitH Mukhtar

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