Trans-sulfuration Pathway Seleno-amino Acids Are Mediators of Selenomethionine Toxicity in Saccharomyces cerevisiae.

The Journal of Biological Chemistry
Myriam LazardPierre Plateau

Abstract

Toxicity of selenomethionine, an organic derivative of selenium widely used as supplement in human diets, was studied in the model organism Saccharomyces cerevisiae. Several DNA repair-deficient strains hypersensitive to selenide displayed wild-type growth rate properties in the presence of selenomethionine indicating that selenide and selenomethionine exert their toxicity via distinct mechanisms. Cytotoxicity of selenomethionine decreased when the extracellular concentration of methionine or S-adenosylmethionine was increased. This protection resulted from competition between the S- and Se-compounds along the downstream metabolic pathways inside the cell. By comparing the sensitivity to selenomethionine of mutants impaired in the sulfur amino acid pathway, we excluded a toxic effect of Se-adenosylmethionine, Se-adenosylhomocysteine, or of any compound in the methionine salvage pathway. Instead, we found that selenomethionine toxicity is mediated by the trans-sulfuration pathway amino acids selenohomocysteine and/or selenocysteine. Involvement of superoxide radicals in selenomethionine toxicity in vivo is suggested by the hypersensitivity of a Δsod1 mutant strain, increased resistance afforded by the superoxide scavenger mangan...Continue Reading

References

Jul 1, 1992·Archives of Biochemistry and Biophysics·J ChaudiereJ Leclaire
Mar 1, 1969·Archives of Biochemistry and Biophysics·R C Dickson, A L Tappel
Oct 1, 1967·Archives of Biochemistry and Biophysics·R E Huber, R S Criddle
Jun 2, 1995·The Journal of Biological Chemistry·P R GardnerC W White
Jun 1, 1994·Computer Applications in the Biosciences : CABIOS·F Dardel
Jul 1, 1994·Free Radical Biology & Medicine·J E Spallholz
Jan 22, 2002·Nutrition and Cancer·R Gopalakrishna, U Gundimeda
Apr 17, 2004·Ecotoxicology and Environmental Safety·Vince P PalaceChristopher L Baron
Nov 12, 2005·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Raylene J SanchezJoan Selverstone Valentine
Aug 29, 2006·Toxicology·Lucia LetavayováJela Brozmanová
Apr 12, 2007·Proceedings of the National Academy of Sciences of the United States of America·Michael G MalkowskiElizabeth J Grayhack
Sep 29, 2007·Mutation Research·Lucia LetavayováMiroslav Chovanec
Oct 4, 2007·Journal of Biochemical and Molecular Toxicology·Grace ChanBlase Billack
Apr 22, 2008·Mutation Research·Lucia LetavayováMiroslav Chovanec
Jul 11, 2008·Fungal Genetics and Biology : FG & B·Anna Lewinska, Grzegorz Bartosz
Nov 14, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jessica BockhornTerri Goss Kinzy
Jan 27, 2009·Journal of Inorganic Biochemistry·Jason L LarabeeJay S Hanas
Nov 13, 2009·Antioxidants & Redox Signaling·Laura V PappKum Kum Khanna
Dec 25, 2009·Archives of Toxicology·Vanessa ValdiglesiasBlanca Laffon
Aug 10, 2010·Applied and Environmental Microbiology·Toshihiko KitajimaYoshifumi Jigami
Sep 28, 2010·Archives of Toxicology·Jela BrozmanováMiroslav Chovanec
Feb 15, 2011·Biochimica Et Biophysica Acta·Sangita Singh, Ruma Banerjee
Feb 9, 2012·The Journal of Biological Chemistry·Toshihiko KitajimaYasunori Chiba
May 16, 2012·PloS One·Gérald PeyrochePierre Plateau
Jul 4, 2012·Chemical Research in Toxicology·Dominika MánikováMiroslav Chovanec
Sep 29, 2012·Biochimica Et Biophysica Acta·Oksana TehlivetsWalter Keller
Oct 23, 2012·IUBMB Life·Aldwin Suryo Rahmanto, Michael J Davies

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Citations

Mar 25, 2017·Molecular Medicine Reports·Marco VincetiMargherita Ferrante
Jun 3, 2017·Biomolecular Concepts·Myriam LazardPierre Plateau
Jan 22, 2019·Protein Science : a Publication of the Protein Society·Sabine WenzelYuichiro Takagi
Oct 6, 2020·Thyroid Research·Leonidas H Duntas
Dec 20, 2018·Nutrients·Lindsay N KohlerElizabeth T Jacobs
Mar 25, 2018·Free Radical Biology & Medicine·Lucia A SealeMarla J Berry

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