Oct 12, 2013

Trans-synaptic axonal degeneration in the visual pathway in multiple sclerosis

Annals of Neurology
Iñigo GabilondoPablo Villoslada

Abstract

To evaluate the association between the damage to the anterior and posterior visual pathway as evidence of the presence of retrograde and anterograde trans-synaptic degeneration in multiple sclerosis (MS). We performed a longitudinal evaluation on a cohort of 100 patients with MS, acquiring retinal optical coherence tomography to measure anterior visual pathway damage (peripapillary retinal nerve fiber layer [RNFL] thickness and macular volume) and 3T brain magnetic resonance imaging (MRI) for posterior visual pathway damage (volumetry and spectroscopy of visual cortex, lesion volume within optic radiations) at inclusion and after 1 year. Freesurfer and SPM8 software was used for MRI analysis. We evaluated the relationships between the damage in the anterior and posterior visual pathway by voxel-based morphometry (VBM), multiple linear regressions, and general linear models. VBM analysis showed that RNFL thinning was specifically associated with atrophy of the visual cortex and with lesions in optic radiations at study inclusion (p < 0.05). Visual cortex volume (β = +0.601, 95% confidence interval [CI] = +0.04 to +1.16), N-acetyl aspartate in visual cortex (β = +1.075, 95% CI = +0.190 to +1.961), and lesion volume within optic ...Continue Reading

  • References38
  • Citations76
  • References38
  • Citations76

Citations

Mentioned in this Paper

Optic Tract Structure
Visual System
N-acetylaspartate
Abnormal Degeneration
Adrenal Cortex Diseases
Magnetic Resonance Imaging
Nerve Degeneration
Nerve Fibers
Retrograde Degeneration
Incidence Studies

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