Trans-urethral whole layer core biopsy for detection of residual tumor after neoadjuvant therapy in invasive bladder cancer

Urologic Oncology
S HoshiS Orikasa

Abstract

The most essential information necessary for the treatment of bladder cancer is to know its exact staging. We have developed a percutaneous whole layer core biopsy (PC-WLCB) of the bladder tumor and applied it successfully since April 1985 for the staging and evaluation of neoadjuvant therapy in locally invasive bladder cancer. We report here a modified method, the trans-urethral WLCB (TU-WLCB) and present its clinical results. Methods: A 20 F. rigid nephroscope was introduced trans-urethrally and an 18 gauge, 350mm-long biopsy needle or newly developed 450mm-long biopsy needle was advanced to the tumor through the nephroscope. Biopsy was performed under trans-abdominal ultrasound guidance. Results: Specimens of all 20 TU-WLCB cases included the muscle layer and adipose tissue, and demonstrated small focus of residual cancers after neoadjuvant therapy. Serious complications were not observed so far. Conclusion: TU-WLCB may prove to be a reliable method to stage and evaluate neoadjuvant therapy for invasive bladder cancer.

References

Dec 1, 1988·British Journal of Urology·F H SchröderR Sylvester
Jan 1, 1993·Scandinavian Journal of Urology and Nephrology·P U MalmströmA Magnusson
Aug 31, 1999·International Journal of Urology : Official Journal of the Japanese Urological Association·S HoshiK Ono

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Citations

Aug 31, 1999·International Journal of Urology : Official Journal of the Japanese Urological Association·S HoshiK Ono
Nov 30, 2011·Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses·Lyn Vargo, Istvan Seri
Jul 15, 2003·The Tohoku Journal of Experimental Medicine·Shinichi YamashitaYoichi Arai
Jul 25, 2008·International Journal of Urology : Official Journal of the Japanese Urological Association·Piotr ChłostaAndrzej Borówka

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