Trans ε viniferin decreases amyloid deposits and inflammation in a mouse transgenic Alzheimer model

PloS One
Martial CaillaudAgnès Rioux Bilan

Abstract

As Alzheimer's disease (AD) induces several cellular and molecular damages, it could be interesting to use multi-target molecules for therapeutics. We previously published that trans ε-viniferin induced the disaggregation of Aβ42 peptide and inhibited the inflammatory response in primary cellular model of AD. Here, effects of this stilbenoid were evaluated in transgenic APPswePS1dE9 mice. We report that trans ε-viniferin could go through the blood brain barrier, reduces size and density of amyloid deposits and decreases reactivity of astrocytes and microglia, after a weekly intraperitoneal injection at 10 mg/kg from 3 to 6 months of age.

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Citations

Nov 14, 2019·Neural Regeneration Research·Aline FreyssinAgnès Rioux Bilan
May 5, 2020·Frontiers in Aging Neuroscience·Bruno Dutra ArboMariana Appel Hort
Jan 15, 2021·Neurochemistry International·Manoj GovindarajuluMuralikrishnan Dhanasekaran
Mar 23, 2021·Journal of Alzheimer's Disease : JAD·Roger GaudreaultCharles Ramassamy

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Methods Mentioned

BETA
transgenic
protein
ELISA
protein assay

Software Mentioned

Graph Pad Prism
ImageJ
GraphPad
CREPTA
GraphPad Instat
image J

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