PMID: 6129302Nov 1, 1982

Transamination and other metabolic pathways of 3,4-dihydroxyphenylpyruvic acid in rats when simultaneously administered with L-dopa

The Journal of Pharmacy and Pharmacology
I B LindénA Penttilä

Abstract

In the rat, 3,4-dihydroxyphenylpyruvic acid (DHPPA) was shown to be transaminated to L-dopa when administered orally concomitantly with L-[3H]dopa. As much as 40% of the serum L-dopa and brain dopamine was shown to be formed via transamination. Moreover, it was shown that DHPPA also caused a so-called L-dopa-sparing effect, i.e. more administered L-dopa reached the circulation and consequently more dopamine reached its target than after administration of L-dopa alone. This effect might be due to an inhibition of the deamination of L-[3H]dopa, since in this case the equilibrium of the transamination reaction will be forced into the L-dopa-forming direction. After administration of [14C]DHPPA alone and together with L-dopa, no differences in the absorption and distribution of radioactivity were found.

References

Jun 1, 1976·Journal of Pharmaceutical Sciences·S CotlerS A Kaplan
Sep 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·S S TateA Meister
Jan 1, 1931·The Biochemical Journal·C R Harington, S S Randall

Citations

Oct 18, 2006·Clinical and Experimental Pharmacology & Physiology·Mei WuYong-Xiang Wang
Nov 1, 1982·Acta Pharmacologica Et Toxicologica·I B Lindén, S Niemi
Sep 1, 1982·Acta Pharmacologica Et Toxicologica·I B LindénH Vapaatalo

Related Concepts

3,4-dihydroxyphenylpyruvic acid, alpha-(14)C-labeled
Metabolic Biotransformation
Brain Chemistry
Intropin
Levopa
Phenylpyruvic Acids
August Rats

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