Transamination reactions with multiple turnovers catalyzed by hydrophobic pyridoxamine cofactors in the presence of polyethylenimine polymers

Journal of the American Chemical Society
Lei LiuRonald Breslow

Abstract

Pyridoxamines carrying hydrophobic side chains reversibly bind into the hydrophobic core of polyethylenimines and transaminate ketoacids to amino acids with as much as a 725000-fold rate acceleration. Turnover catalysis was achieved by sacrificial oxidative decarboxylation of C-substituted amino acids, which reconverted the pyridoxals to pyridoxamines.

References

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Aug 21, 2001·The Journal of Organic Chemistry·F HollfelderD S Tawfik
May 2, 2002·Journal of the American Chemical Society·Lei Liu, Ronald Breslow
Oct 24, 2002·Journal of the American Chemical Society·Lei LiuRonald Breslow
Oct 2, 2003·Journal of the American Chemical Society·Lei Liu, Ronald Breslow

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Citations

Nov 17, 2009·Origins of Life and Evolution of the Biosphere : the Journal of the International Society for the Study of the Origin of Life·Ronald BreslowZhan-Ling Cheng
Jun 15, 2005·Bioorganic & Medicinal Chemistry·Jason J ChrumaRonald Breslow
Sep 4, 2008·Journal of the American Chemical Society·Huanyu ZhaoRonald Breslow
Feb 24, 2007·Organic Letters·Subhajit BandyopadhyayRonald Breslow
Jul 21, 2016·Organic Letters·Xiaoyu LanBaoguo Zhao
Sep 16, 2006·Chembiochem : a European Journal of Chemical Biology·Ronald BreslowWenjun Zhou
Oct 4, 2014·Chemistry : a European Journal·Emil LindbäckKenneth Wärnmark
Oct 26, 2018·Angewandte Chemie·Yoan ChevalierFrédéric Avenier
Jul 26, 2008·Chembiochem : a European Journal of Chemical Biology·Liisa D Van VlietFlorian Hollfelder
Sep 26, 2008·Chemistry : a European Journal·Hyunjung ParkKwan Mook Kim
Oct 3, 2009·Chemistry : a European Journal·Frédéric Avenier, Florian Hollfelder
Mar 28, 2008·Journal of Computational Chemistry·Rong-Zhen LiaoRuo-Zhuang Liu
Sep 12, 2008·The Journal of Biological Chemistry·Ronald Breslow
Aug 13, 2013·Natural Product Reports·Michael Richter
Sep 30, 2013·Biomaterials Science·Xuanjun WuShoufa Han
Dec 25, 2013·Chemical Society Reviews·Matthieu RaynalPiet W N M van Leeuwen
Nov 20, 2019·European Journal of Medicinal Chemistry·Haibo MeiVadim A Soloshonok
Aug 14, 2020·The Journal of Organic Chemistry·Haruki InadaYoshihiko Yamamoto
May 11, 2010·The Journal of Physical Chemistry. a·Jing ShiRun Li
Dec 18, 2007·Organic Letters·Susanne StrieglerMichael Dittel
Oct 12, 2018·Chemical Reviews·Shaojian TangJason J Chruma
Sep 1, 2021·Nature Communications·Weiqi CaiBaoguo Zhao
Jun 22, 2007·Organic Letters·Andrew A Yeagley, Jason J Chruma
Nov 4, 2021·Journal of the American Chemical Society·Robert J MayerJoseph Moran
Dec 3, 2021·Organic & Biomolecular Chemistry·Rui NiuJun-Bing Lin

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