Abstract
To evaluate a new transapical system which utilizes a novel designed positioning element and a two-step positioning mechanism for easy and accurate implantation of transcatheter valves. Transcatheter aortic valve implantation is an important treatment option for non-surgical patients with severe aortic stenosis. However, accurate placement of the transcatheter valve remains challenging. Self-expandable aortic valve prosthesis with a flexibly connected, annulus-like positioning element was implanted through a transapical approach in 12 pigs. The positioning element was separated and can be released independent of the valve prosthesis. During valve implantation, firstly, the positioning element was unsheathed and fixed into the aortic sinus. Then, the prosthetic valve was guided to an anatomically oriented position and deployed. Six animals were followed up to 180 days. With the help of the positioning element, all 12 valves were successfully deployed at the anticipated site. The valve release procedure took an average of 7.3 ± 2.5 min. The mean transvalvular pressure gradient was 2.8 ± 1.1 mm Hg at valve deployment. Of the six chronic animals, the mean transvalvular pressure gradient was 3.0 ± 1.0 mm Hg on day 7, and 2.9 ± 1.6 m...Continue Reading
References
May 13, 2009·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Alexander LautenHans R Figulla
Jun 23, 2010·Circulation·Martyn ThomasOlaf Wendler
Oct 22, 2010·The New England Journal of Medicine·Martin B LeonUNKNOWN PARTNER Trial Investigators
Dec 15, 2010·European Heart Journal·Volkmar FalkFriedrich W Mohr
Jan 12, 2011·Circulation·Corrado TamburinoGian Paolo Ussia
Mar 15, 2011·Heart·Mohamed Abdel-WahabUNKNOWN German transcatheter aortic valve interventions registry investigators
Jun 7, 2011·The New England Journal of Medicine·Craig R SmithUNKNOWN PARTNER Trial Investigators
Sep 20, 2011·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Jörg KempfertThomas Walther
Nov 16, 2011·Nature Reviews. Cardiology·Josep Rodés-Cabau
Mar 24, 2012·Journal of the American College of Cardiology·Jan-Malte SinningNikos Werner
Apr 18, 2012·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Hendrik TreedeHans-Reiner Figulla
Jun 30, 2012·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Simon H SündermannSabine Bleiziffer
Sep 22, 2012·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Christos V BourantasPatrick W Serruys
May 21, 2013·JACC. Cardiovascular Interventions·Moritz SeiffertHendrik Treede
Sep 12, 2013·European Heart Journal·Christian W HammUNKNOWN GARY-Executive Board
Jan 18, 2014·The Journal of Thoracic and Cardiovascular Surgery·Philipp KieferDavid M Holzhey
Citations
Apr 7, 2020·Annals of Thoracic and Cardiovascular Surgery : Official Journal of the Association of Thoracic and Cardiovascular Surgeons of Asia·Fei LiWei Wang
Jul 30, 2020·Current Cardiology Reports·Ryan MarkhamR Sharma
Jan 19, 2021·Annals of Thoracic and Cardiovascular Surgery : Official Journal of the Association of Thoracic and Cardiovascular Surgeons of Asia·Fei LiWei Wang
Nov 17, 2020·International Heart Journal·Fei LiWei Wang