Transauricular embolization of the rabbit coronary artery for experimental myocardial infarction: comparison of a minimally invasive closed-chest model with open-chest surgery.

Journal of Cardiothoracic Surgery
Konstantinos KatsanosDimitris Siablis

Abstract

To date, most animal studies of myocardial ischemia have used open-chest models with direct surgical coronary artery ligation. We aimed to develop a novel, percutaneous, minimally-invasive, closed-chest model of experimental myocardial infarction (EMI) in the New Zealand White rabbit and compare it with the standard open-chest surgical model in order to minimize local and systemic side-effects of major surgery. New Zealand White rabbits were handled in conformity with the "Guide for the Care and Use of Laboratory Animals" and underwent EMI under intravenous anesthesia. Group A underwent EMI with an open-chest method involving surgical tracheostomy, a mini median sternotomy incision and left anterior descending (LAD) coronary artery ligation with a plain suture, whereas Group B underwent EMI with a closed-chest method involving fluoroscopy-guided percutaneous transauricular intra-arterial access, superselective LAD catheterization and distal coronary embolization with a micro-coil. Electrocardiography (ECG), cardiac enzymes and transcatheter left ventricular end-diastolic pressure (LVEDP) measurements were recorded. Surviving animals were euthanized after 4 weeks and the hearts were harvested for Hematoxylin-eosin and Masson-tri...Continue Reading

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Citations

Jul 17, 2013·The Journal of Thoracic and Cardiovascular Surgery·Sofoklis MitsosDimitrios Dougenis
Mar 19, 2016·Regulatory Toxicology and Pharmacology : RTP·Mukesh Kumar BudhaniVikas Kumar
Jan 24, 2017·The Journal of Veterinary Medical Science·Mei-Yun TanYong-Can Huang
Jun 24, 2016·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Grigorios TsigkasDimitrios Alexopoulos
Aug 19, 2018·Basic Research in Cardiology·Hans Erik BøtkerGerd Heusch

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