Transcapillary escape rate of albumin in type II diabetic patients. The relationship with microalbuminuria and hypertension

Diabetes Care
M NannipieriR Navalesi

Abstract

To study why in type II diabetes, microalbuminuria, a marker of generalized vascular dysfunction, and hypertension have been linked with both renal and cardiovascular organ damage. To investigate the effect of moderately elevated blood pressure on vascular damage, the transcapillary escape rate of albumin (TERalb) was measured by intravenous injection of purified 125I-human serum albumin in 9 healthy control subjects (group 1), 9 nondiabetic hypertensive subjects (group 2), and 73 nonobese type II diabetic patients stratified as follows: group 3: 17 normoalbuminuric-normotensive subjects; group 4: 22 normoalbuminuric-hypertensive subjects (systolic blood pressure [sBP] > or = 140 mmHg or diastolic blood pressure [dBP] > or = mmHg or both); group 5: 16 normotensive subjects with microalbuminuria (albumin excretion rate [AER]: 20-200 micrograms/min); and group 6: 18 microalbuminuric-hypertensive subjects. Groups 3-6 had similar age, sex, duration of diabetes (group 3: 7.8 +/- 5.5; group 4: 9.7 +/- 8.7; group 5: 12.1 +/- 8.1; and group 6: 10.7 +/- 8.3 years), BMI, HbA1c (7.8 +/- 1.1, 7.5 +/- 1.5, 8.7 +/- 1.5, and 7.7 +/- 1.1%, respectively), blood glucose, and lipid profile. Systolic and diastolic blood pressure did not differ in ...Continue Reading

Citations

Mar 20, 2003·Current Diabetes Reports·Kevin RowleyJames D Best
Dec 15, 2000·European Journal of Clinical Investigation·G TonoloM Maioli
Jun 24, 2006·Journal of Cardiovascular Pharmacology·Peter OchodnickyDick de Zeeuw
May 11, 2016·Journal of the American Society of Nephrology : JASN·Remy J H MartensCoen D A Stehouwer
Jun 21, 2016·Nature Reviews. Nephrology·Peter Boor
Jul 23, 2013·Clinical Journal of the American Society of Nephrology : CJASN·Rikki M TannerPaul Muntner
Jan 18, 2002·Journal of the American Podiatric Medical Association·Patricia L Abu-RummanBrent P Nixon
Apr 25, 2000·American Journal of Hypertension·R PedrinelliM Mariani
Feb 17, 2021·EJNMMI Radiopharmacy and Chemistry·Youssef ChahidHein J Verberne
Jul 15, 1999·Journal of the American Society of Nephrology : JASN·M NannipieriR Navalesi

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