PMID: 3749787Sep 1, 1986Paper

Transcapillary forces in subcutaneous tissue of lower limbs with deep venous thrombosis

Scandinavian Journal of Clinical and Laboratory Investigation
E Seem, E Stranden

Abstract

Starling forces (interstitial fluid pressure, plasma- and interstitial fluid colloid osmotic pressures) were measured in the subcutaneous tissue of legs in 22 patients with deep venous thrombosis (DVT). For comparison, measurements were obtained in the contralateral leg and in healthy controls as well. Interstitial fluid pressure (Pif) was measured with the 'wick-in-needle' technique and we found a significantly higher pressure in limbs with DVT compared to contralateral limbs and controls. Interstitial fluid was collected from subcutaneous tissue with the 'wick technique'. Colloid osmotic pressure was measured in wick interstitial fluid (COPif) and plasma (COPpl) with an osmometer. A significant reduction of COPif was found in limbs with DVT compared to the contralateral side and controls. The COPpl was also significantly reduced in patients compared to controls. Saphenous vein pressure (Pv) measured at the ankle was significantly increased in the thrombosed limb compared to the contralateral. We conclude that the main cause of subcutaneous oedema in DVT of the lower limbs is increased transcapillary filtration caused by a rise in Pv. This leads to a fall in COPif and rise in Pif which act as oedema-preventing mechanisms.

References

Jul 1, 1979·Microvascular Research·C A Wiederhielm
Jul 1, 1977·Microvascular Research·H O FadnesK Aukland
Nov 1, 1985·Acta Radiologica: Diagnosis·E SeemM G Stiris
Feb 1, 1972·Archives of Surgery·K Rabinov, S Paulin
Nov 1, 1983·Acta Physiologica Scandinavica·H V Nielsen
Jul 1, 1981·Physiological Reviews·K Aukland, G Nicolaysen
Sep 1, 1981·Microvascular Research·A R HargensR M Peters
Jul 1, 1932·The Journal of Clinical Investigation·E M LandisW Erb
May 5, 1896·The Journal of Physiology·E H Starling

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Citations

Feb 1, 1987·European Journal of Vascular Surgery·E Seem, E Stranden
Mar 1, 1992·European Journal of Vascular Surgery·R HaaverstadP A Rinck

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