Transcardiac 8-iso-prostaglandin F(2 alpha)generation from acute myocardial infarction heart: insight into abrupt reperfusion and oxidant stress

Prostaglandins, Leukotrienes, and Essential Fatty Acids
Y KijimaM Fukunaga

Abstract

8-iso-prostaglandin F(2 alpha)(8-iso-PGF(2 alpha)), a representative isoprostane, has been reported to be a reliable marker for oxidant stress in vivo. To examine if 8-iso-PGF(2 alpha)is generated in patients with acute myocardial infarction (AMI), we measured the level of immunoreactive 8-iso PGF(2 alpha)in the great cardiac vein as well as classical eicosanoids, 6-keto-prostaglandin F(1 alpha)(6-keto-PGF(1 alpha)) and thromboxane B(2)(TXB(2)) in the process of urgent coronary balloon angioplasty. Fourteen patients with anterior AMI were divided into two groups: the totally occluded (n=7) and the already perfused groups (n=7). In the former, transient elevation of 8-iso-PGF(2 alpha)was observed immediately after the angioplasty, i.e. the ratio of post-angioplasty level to pre-level was approximately 2.4 for 8-iso-PGF(2 alpha), 14 for 6-keto-PGF(1 alpha), and 5 for TXB(2). In the already perfused group, the levels of these eicosanoids were unchanged. In the totally occluded group, peak creatine phosphokinase in a peripheral vein was correlated with the level of 8-iso-PGF(2 alpha)(r(2)=0.841, P<0.01), but not with those of the other two eicosanoids. In conclusion, transcardiac 8-iso-PGF(2 alpha)generation is a reliable marker fo...Continue Reading

References

Nov 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·J D MorrowL J Roberts
Oct 23, 1997·The Journal of Clinical Investigation·D PraticòG A FitzGerald
Mar 1, 1997·Progress in Lipid Research·J D Morrow, L J Roberts

❮ Previous
Next ❯

Citations

Jan 15, 2005·Antioxidants & Redox Signaling·Samar Basu, Johanna Helmersson
Apr 28, 2005·Clinical and Experimental Pharmacology & Physiology·Claire ArnaudChristophe Ribuot
Nov 27, 2007·Circulation Journal : Official Journal of the Japanese Circulation Society·Megumi KunishigeTakeshi Hata
May 8, 2008·Prostaglandins, Leukotrienes, and Essential Fatty Acids·A NishibeT Hata
Jan 23, 2003·The Journal of Thoracic and Cardiovascular Surgery·Uwe MehlhornWilhelm Bloch
May 22, 2007·Journal of the American College of Cardiology·Tessa J MocattaChristine C Winterbourn
Oct 30, 2008·Nature Clinical Practice. Cardiovascular Medicine·Alexander J J IjsselmuidenWalter J Paulus
Nov 6, 2003·American Journal of Physiology. Cell Physiology·Andrea Dallas, Raouf A Khalil
Feb 15, 2002·Current Opinion in Clinical Nutrition and Metabolic Care·Yvon A Carpentier, Olivier Scruel

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aphasia

Aphasia affects the ability to process language, including formulation and comprehension of language and speech, as well as the ability to read or write. Here is the latest research on aphasia.