Transcatheter aortic valve implantation.

Current Treatment Options in Cardiovascular Medicine
Samir R Kapadia, E Murat Tuzcu

Abstract

Aortic stenosis is the most important valvular heart disease affecting the elderly population. Surgical aortic valve replacement is the mainstay of treatment, although a substantial number of patients are considered high risk for surgery. Many of these patients do not undergo surgery and have poor outcomes from medically treated symptomatic, severe aortic stenosis. Transcatheter aortic valve implantation (TAVI) provides a promising treatment option for some of these patients. Several devices are under investigation. The Edwards Sapien valve (Edwards Lifesciences, Irvine, CA) and the CoreValve (Medtronic, Minneapolis, MN) have the largest human experience to date. Initial data suggest that these devices have an acceptable safety profile and provide excellent hemodynamic relief of aortic stenosis. The Edwards Sapien valve is currently under investigation in the United States in the PARTNER (Placement of Aortic Transcatheter Valve) trial in high-risk surgical or inoperable patients; TAVI is available for clinical use in both Canada and Europe. TAVI is not used in low- or intermediate-risk surgical patients; however, future studies may prove its applicability in these subsets. The major complications of TAVI include access site-rel...Continue Reading

References

Apr 1, 1988·European Heart Journal·D Horstkotte, F Loogen
Apr 1, 1980·American Heart Journal·M A ChiznerA C deLeon
Apr 1, 1993·Journal of the American College of Cardiology·M LindroosR Tilvis
Jul 1, 1996·The American Journal of Cardiology·A M IivanainenM Kupari
Feb 19, 2005·Current Cardiology Reports·Peter C Block, Philipp Bonhoeffer
May 4, 2005·The Journal of Thoracic and Cardiovascular Surgery·Thomas A VassiliadesUNKNOWN Society for Cardiovascular Angiography and Interventions
Oct 7, 2005·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Eberhard GrubeStein Iversen
Feb 8, 2006·Circulation·John G WebbSamuel Lichtenstein
Sep 19, 2006·Lancet·Vuyisile T NkomoMaurice Enriquez-Sarano
Nov 14, 2006·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Thomas WaltherFriedrich W Mohr
Nov 28, 2006·The Annals of Thoracic Surgery·Padmini VaradarajanRamdas G Pai
Nov 28, 2006·The Annals of Thoracic Surgery·Ramdas G PaiPadmini Varadarajan
Nov 28, 2006·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Jian YeJohn G Webb
Nov 13, 2007·Journal of the American College of Cardiology·David S BachG Michael Deeb
Feb 24, 2009·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Sabine BleizifferRuediger Lange
May 16, 2009·Journal of the American College of Cardiology·Alan Zajarias, Alain G Cribier
May 16, 2009·Journal of the American College of Cardiology·John G WebbRobert A Boone
May 21, 2009·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Samir R KapadiaE Murat Tuzcu

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Citations

Feb 22, 2011·The International Journal of Cardiovascular Imaging·Thomas J HeltonE Murat Tuzcu
Sep 9, 2010·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Amar KrishnaswamySamir R Kapadia
Oct 23, 2014·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Lurdes TseAlasdair M Barr

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