Transcatheter Aortic Valve Replacement for Degenerated Transcatheter Aortic Valves: The TRANSIT International Project.

Circulation. Cardiovascular Interventions
Luca TestaFrancesco Bedogni

Abstract

Transcatheter aortic valve replacement (TAVR) has determined a paradigm shift in the treatment of patients with severe aortic stenosis. However, the durability of bioprostheses is still a matter of concern, and little is known about the management of degenerated TAV. We sought to evaluate the outcomes of patients with a degenerated TAV treated by means of a second TAVR. The TRANSIT is an international registry that included cases of degenerated TAVR from 28 centers. Among around 40 000 patients treated with TAVR in the participating centers, 172 underwent a second TAVR: 57 (33%) for a mainly stenotic degenerated TAV, 97 (56%) for a mainly regurgitant TAV, and 18 (11%) for a combined degeneration. Overall, the rate of New York Heart Association class III/IV at presentation was 73.5%. Valve Academic Research Consortium 2 device success rate was 79%, as a consequence of residual gradient (14%) or regurgitation (7%). At 1 month, the overall mortality rate was 2.9%, while rates of new hospitalization and New York Heart Association class III/IV were 3.6% and 7%, respectively, without significant difference across the groups. At 1 year, the overall mortality rate was 10%, while rates of new hospitalization and New York Heart Associati...Continue Reading

References

Jul 1, 1978·Circulation·S H Rahimtoola
Sep 19, 2016·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Tobias SchmidtMohamed Abdel-Wahab
May 8, 2018·Journal of the American Heart Association·Luca TestaFrancesco Bedogni
May 21, 2018·JACC. Cardiovascular Imaging·Erwan SalaunJosep Rodés-Cabau
Sep 27, 2018·Journal of the American College of Cardiology·Thomas G GleasonUNKNOWN CoreValve U.S. Pivotal High Risk Trial Clinical Investigators
Mar 19, 2019·The New England Journal of Medicine·Jeffrey J PopmaUNKNOWN Evolut Low Risk Trial Investigators
Mar 19, 2019·The New England Journal of Medicine·Michael J MackUNKNOWN PARTNER 3 Investigators
Jan 30, 2020·The New England Journal of Medicine·Raj R MakkarUNKNOWN PARTNER 2 Investigators
Apr 20, 2020·JACC. Cardiovascular Interventions·Mohamed Abdel-WahabUNKNOWN CHOICE Investigators
Apr 25, 2020·Journal of the American College of Cardiology·Uri LandesMarco Barbanti
Oct 17, 2020·Journal of the American College of Cardiology·Sameer A HirjiTsuyoshi Kaneko
Nov 21, 2020·JACC. Cardiovascular Interventions·Tomoki OchiaiRaj Makkar
Nov 21, 2020·JACC. Cardiovascular Interventions·Ole De Backer, Lars Søndergaard

❮ Previous
Next ❯

Citations

Jun 8, 2021·Circulation. Cardiovascular Interventions·Marco Barbanti, Giuliano Costa

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Current Cardiology Reports
Anna FranzoneStephan Windecker
Circulation Journal : Official Journal of the Japanese Circulation Society
In-Chang HwangHyo-Soo Kim
Minerva cardioangiologica
Lucia JunqueraJosep Rodés-Cabau
Expert Review of Medical Devices
Oren M RotmanDanny Bluestein
© 2021 Meta ULC. All rights reserved