Transcatheter paravalvular leak closure and hemolysis - a prospective registry

Archives of Medical Science : AMS
Grzegorz SmolkaWojciech Wojakowski

Abstract

Paravalvular leak (PVL) related to a surgical prosthetic valve may be associated with clinically significant hemolysis. The influence of transcatheter PVL closure (TPVLC) on hemolysis remains uncertain. The prospective registry included patients undergoing TPVLC due to PVL-related heart failure and/or hemolysis. Procedural data, laboratory markers of hemolysis and heart failure status were recorded at baseline, discharge and at 1- and 6-month follow-up. Of 116 patients from all those qualified for TPVLC, 79 fulfilled the inclusion/exclusion criteria. Hemolysis was significantly more frequent in patients with mitral location of PVL and with calcifications in its channel. After TPVLC prompt reduction of lactate dehydrogenase activity (617.0 (342.0-899.0) vs. 397 (310.0-480.5) IU/l, p < 0.05) and gradual resolution of anemia (hemoglobin (HGB) 11.7 (10.4-13.8) vs. 13.4 (12.9-13.8) g%, p < 0.05) over 6 months were noted. Effective closure of PVL (> 90% reduction of PVL cross-sectional area) resulted in a more prominent increase of red blood cell count and HGB than in patients with residual regurgitation. The TPVLC-related exacerbation of hemolysis was recorded in 14 patients. Its risk was aggravated by presence of significant hemoly...Continue Reading

Citations

May 1, 2019·Clinical Cardiology·Mohamad AlkhouliChalak Berzingi
Oct 11, 2020·Current Cardiology Reports·Elias J FanousAsim M Rafique
Sep 2, 2021·Seminars in Cardiothoracic and Vascular Anesthesia·Ellen W RichterSujatha P Bhandary
Nov 26, 2021·Journal of Cardiac Surgery·Imran Karim JanmohamedAmer Harky

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Methods Mentioned

BETA
coronary artery bypass

Software Mentioned

SAS
JMP

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